Phenotypes associated with this allele
Allelic
Composition |
CryaaL1N/CryaaL1N
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Genetic
Background |
involves: C3H/HeN * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CryaaL1N mutation
(0 available);
any
Cryaa mutation
(14 available)
|
|
|
vision/eye
|
|
• mice show much denser nuclear cataracts than heterozygtes at weaning age
|
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• at 3 weeks, wet weight of homozygous lenses is 2.87 mg compared to 3.55 mg in wild-type (7% less)
|
Allelic
Composition |
CryaaL1N/Cryaa+
|
|
Genetic
Background |
involves: C3H/HeN * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CryaaL1N mutation
(0 available);
any
Cryaa mutation
(14 available)
|
|
|
vision/eye
|
|
• at 3 weeks, wet weight of heterozygous lenses is 3.31 mg compared to 3.55 mg in wild-type (19% less)
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CryaaL1N mutation
(0 available);
any
Cryaa mutation
(14 available)
Tg(CAG-EGFP)1Osb mutation
(8 available)
|
|
|
vision/eye
|
N |
• histology shows no obvious changes in lens epithelial and fiber cells at weaning age
|
|
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• analysis shows that mutant lenses contain a greater amount of water-insoluble crystallin proteins, likely correlating with the nuclear cataracts observed in mice
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Analysis Tools