Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(MAML1)Wsp mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• serum levels of T. muris-specific IgG1 are decreased compared to controls, IgG2a levels are increased, and total IgE is lower in infected mutants
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• under neutral and Th2 conditions, interferon gamma (Ifng)-producing cells increase in culture compared to controls; under Th1 conditions, there is no change in percentage of Ifng-producing cells
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• Th2 cell differentiation is impaired in culture compared to control CD4 trangenic mice
• under Th2 cell conditions, percentage of T cells expressing Il-4 is lower than in control cultures
• Th2 cytokine production is lower in mice after inoculation with T. muris (helminth)
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• mice are resistant to Leishmania major infection; parasitic replication is controlled and lesions are resolved compared to BALB/c controls
• lymph node cells produce abundant amounts of Ifng
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• mutants are unable to fight infection by T. muris, a helminthic pathogen
• Th2-dependent goblet cell and mucin responses are absent at day 21 after infection
• mice have a higher worm burden than control CD4 transgenic mice; at 32 days after inoculation, infection is still present
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hematopoietic system
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• serum levels of T. muris-specific IgG1 are decreased compared to controls, IgG2a levels are increased, and total IgE is lower in infected mutants
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• under neutral and Th2 conditions, interferon gamma (Ifng)-producing cells increase in culture compared to controls; under Th1 conditions, there is no change in percentage of Ifng-producing cells
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• Th2 cell differentiation is impaired in culture compared to control CD4 trangenic mice
• under Th2 cell conditions, percentage of T cells expressing Il-4 is lower than in control cultures
• Th2 cytokine production is lower in mice after inoculation with T. muris (helminth)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(MAML1)Wsp mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(KRT14-rtTA)F42Efu mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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vision/eye
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• CD45+ leukocyte infiltration is seen in the sub-conjunctival stroma 3-4 days after eyelid opening, at P16, of pups treated with doxycycline
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• epithelial cells of the ocular surface of pups treated with doxycycline (via nursing moms) are hyperplastic and aberrantly desquamated from the conjunctiva
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• pulse doxycycline induction from P0 to P16 results in mutants with severe ulceration and neovascularization in the cornea, even after 180 days post-doxycycline induction
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• the aberrantly desquamated cells within the conjunctival sac are composed of conjunctival epithelial cells and basal cells of stratified epithelia but not corneal epithelial cells, indicating aberrant conjunctival, but not corneal, epithelial cell desquamation
• conjunctival epithelia from pups treated with doxycycline (via nursing moms) exhibit an increase in cell proliferation
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• pups treated with doxycycline (via nursing moms) do not show signs of goblet cell differentiation from the conjunctival epithelium at P9 or P16 unlike controls
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• adult mice administered doxycycline at P90 exhibit loss of goblet cells from the conjunctiva and cellular debris in the conjunctival sac
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• pups from nursing moms administered doxycycline do not exhibit clear conjunctival sacs at P9 as in wild-type pups and instead have a mass of cell debris that is abnormally present in the conjunctival sac, indicating early ocular surface morphogenesis alterations
• adult mice administered doxycycline at P90 exhibit cellular debris in the conjunctival sac
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• pups treated with doxycycline exhibit epidermal metaplasia of corneal epithelium at P16
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• pulse doxycycline induction from P0 to P16 results in mutants with severe ulceration and neovascularization in the cornea, even after 180 days post-doxycycline induction
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cardiovascular system
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• pulse doxycycline induction from P0 to P16 results in mutants with severe ulceration and neovascularization in the cornea, even after 180 days post-doxycycline induction
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immune system
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• CD45+ leukocyte infiltration is seen in the sub-conjunctival stroma 3-4 days after eyelid opening, at P16, of pups treated with doxycycline
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integument
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• adult mice administered doxycycline at P90, exhibit hair loss one month after doxycycline induction, with random alopecia on the body, including the eyelid within 3 months
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(MAML1)Wsp mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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growth/size/body
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• keratin cyst formation is observed
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• generalized growth retardation is observed compared to controls
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neoplasm
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• mice develop spontaneous cutaneous SCC lesions, as well as dysplastic precursor lesions
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limbs/digits/tail
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• with aging, hyperkeratinization of tail is seen
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integument
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• aberrant hair follicle cycling occurs
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• starting at 2-3 weeks, mice display hair and whisker loss; diffuse alopecia is observed
• at 10 months of age, alopecia has progressed almost to completion
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• hypoplastic dermis with increased cellularity is observed
• by 6 months of age, most mice develop hyperkeratotic cutaneous nodules, with all mutants exhibiting multiple lesions by 10 months of age
• examination of some nodules reveals papillomas or inflamed infundibular cyts
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• keratin cyst formation is observed
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• cutaneous nodules show hyperproliferative keratinocytic lesions exhibiting cellular atypia and an invasive growth pattern
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nervous system
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• there is a partial depletion of the progenitor zone in the neural tube of E12.5 embryos
• there is a minor decrease of under 10% in the number of dILB neurons found in embryos
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• mice exhibit a decrease in dILB neurons
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• the progenitor domain is reduced compared to in wild-type mice
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embryo
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• there is a partial depletion of the progenitor zone in the neural tube of E12.5 embryos
• there is a minor decrease of under 10% in the number of dILB neurons found in embryos
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Analysis Tools