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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptger4tm1.2Matb
targeted mutation 2, Matthew D Breyer
MGI:3665234
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptger4tm1.2Matb/Ptger4tm1.2Matb B6.129S6-Ptger4tm1.2Matb MGI:3687319
hm2
 		Ptger4tm1.2Matb/Ptger4tm1.2Matb involves: 129S6/SvEvTac * C57BL/6 MGI:3687279
ht3
 		Ptger4tm1.2Matb/Ptger4+ B6.129S6-Ptger4tm1.2Matb MGI:3687320


Genotype
MGI:3687319
hm1
Allelic
Composition		 Ptger4tm1.2Matb/Ptger4tm1.2Matb
Genetic
Background		 B6.129S6-Ptger4tm1.2Matb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger4tm1.2Matb mutation (0 available); any Ptger4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal calcium ion homeostasis ( J:112753 )
• stimulation of calcium release of calvariae is abrogated in response to prostaglandin E2 or parathyroid hormone




Genotype
MGI:3687279
hm2
Allelic
Composition		 Ptger4tm1.2Matb/Ptger4tm1.2Matb
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger4tm1.2Matb mutation (0 available); any Ptger4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
patent ductus arteriosus ( J:92301 )
• persistent ductus arteriosus

cellular
patent ductus arteriosus ( J:92301 )
• persistent ductus arteriosus




Genotype
MGI:3687320
ht3
Allelic
Composition		 Ptger4tm1.2Matb/Ptger4+
Genetic
Background		 B6.129S6-Ptger4tm1.2Matb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger4tm1.2Matb mutation (0 available); any Ptger4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal calcium ion homeostasis ( J:112753 )
• exhibit a significant decrease in the calcium release response of calvariae to prostaglandin E2 and parathyroid hormone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory