Phenotypes associated with this allele

• Allele Symbol: Tg(Dll1-cre)1Gos
• Allele Name: transgene insertion 1, Achim Gossler
• Allele ID: MGI:3665233
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aldh1a2^tm1Soc/Aldh1a2^tm2Soc Tg(Dll1-cre)1Gos/0	Not Specified	MGI:3665268

Genotype
MGI:3665268

cn1

• Allelic Composition: Aldh1a2^tm1Soc/Aldh1a2^tm2Soc; Tg(Dll1-cre)1Gos/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:112635 )

• at E12.5 at the forelimb level, stunting of the fine branches of dorsally projecting neurons of the radial and ulnar nerves is seen; however ventral projections appear unaffected

decreased motor neuron number ( J:112635 )

• about a 10% and 20% reduction in total motor neuron numbers and lateral motor column lateral motor neurons, respectively, are seen at E12.5 at the forelimb level, but no increase in cell death is detected

• at the hindlimb level at E12.5 a 14% decrease in lateral motor column lateral motor neurons is seen

homeostasis/metabolism

abnormal vitamin A level ( J:112635 )

• 50% reduction in retinoic acid levels in tissue homogenates from the forelimb region

limbs/digits/tail

limbs/digits/tail phenotype ( J:112635 )

N • digit morphology and flexure of the distal limbs are similar to controls in adults