Phenotypes associated with this allele

• Allele Symbol: Gria2^tm3.1Rsp
• Allele Name: targeted mutation 3.1, Rolf Sprengel
• Allele ID: MGI:3665137
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria2^tm3.1Rsp/Gria2^tm3.1Rsp	involves: CD-1	MGI:3588769

Genotype
MGI:3588769

hm1

• Allelic Composition: Gria2^tm3.1Rsp/Gria2^tm3.1Rsp
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal touch/ nociception ( J:96597 )

abnormal nociception after inflammation ( J:96597 )

• increased spontaneous nocifensive responses to intraplantar capsaicin

• significantly more sensitive to thermal and mechanical stimuli than wildtype 24 hours, but not 48 hours, following induction of hindpaw inflammation

hyperalgesia ( J:96597 )

• homozygotes are significantly more sensitive to thermal and mechanical stimuli than wildtype 24 hours, but not 48 hours, following induction of hindpaw inflammation

decreased chemical nociceptive threshold ( J:96597 )

• increase in nociceptive responses in phase II of formalin test and a longer duration of nocifensive behaviors during phase I of the formalin response

nervous system

abnormal spinal cord morphology ( J:96597 )

• number of Ca²⁺-permeable AMPA channels is increased in laminae of the spinal cord

impaired synaptic plasticity ( J:96597 )

• increase in nociceptive activity-induced synaptic plasticity in the spinal dorsal horn

enhanced AMPA-mediated synaptic currents ( J:96597 )

• the AMPA/NMDA peak current ratio and current integral ratio is increased in spinal neurons

• AMPA channel-mediated peak currents on second-order spinal neurons are significantly enhanced