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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chst4tm1Mifu
targeted mutation 1, Minoru Fukuda
MGI:3664734
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chst4tm1Mifu/Chst4tm1Mifu involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3703519
cx2
 		Chst4tm1Mifu/Chst4tm1Mifu
Gcnt1tm1Jxm/Gcnt1tm1Jxm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3703520


Genotype
MGI:3703519
hm1
Allelic
Composition		 Chst4tm1Mifu/Chst4tm1Mifu
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst4tm1Mifu mutation (0 available); any Chst4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:113195 )
• homing of wild-type lymphocytes to peripheral and mesenteric lymph nodes is reduced to 55 and 85% respectively, relative to wild-type recipient mice
• number of lymphocytes in peripheral lymph nodes is decreased to 60% compared to wild-type
impaired leukocyte tethering or rolling ( J:113195 )
• GlyCAM-1 from mutants yield rolling lymphocyte average velocity of 31 um/second, while wild-type GlyCAM-1 yields a rolling velocity of 18 um/second

cellular
abnormal leukocyte migration ( J:113195 )
• homing of wild-type lymphocytes to peripheral and mesenteric lymph nodes is reduced to 55 and 85% respectively, relative to wild-type recipient mice
• number of lymphocytes in peripheral lymph nodes is decreased to 60% compared to wild-type
impaired leukocyte tethering or rolling ( J:113195 )
• GlyCAM-1 from mutants yield rolling lymphocyte average velocity of 31 um/second, while wild-type GlyCAM-1 yields a rolling velocity of 18 um/second

hematopoietic system
abnormal leukocyte migration ( J:113195 )
• homing of wild-type lymphocytes to peripheral and mesenteric lymph nodes is reduced to 55 and 85% respectively, relative to wild-type recipient mice
• number of lymphocytes in peripheral lymph nodes is decreased to 60% compared to wild-type
impaired leukocyte tethering or rolling ( J:113195 )
• GlyCAM-1 from mutants yield rolling lymphocyte average velocity of 31 um/second, while wild-type GlyCAM-1 yields a rolling velocity of 18 um/second




Genotype
MGI:3703520
cx2
Allelic
Composition		 Chst4tm1Mifu/Chst4tm1Mifu
Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst4tm1Mifu mutation (0 available); any Chst4 mutation (18 available)
Gcnt1tm1Jxm mutation (1 available); any Gcnt1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:113195 )
• lymphocyte homing to mesenteric and peripheral lymph nodes in double mutant mice is dramatically decreased to ~25% of that in wild-type
• number of lymphocytes in peripheral lymph nodes is decreased to 40% relative to wild-type
impaired leukocyte tethering or rolling ( J:113195 )
• GlyCAM-1 from double mutant mice supports the least rolling of wild-type lymphocytes

cellular
abnormal leukocyte migration ( J:113195 )
• lymphocyte homing to mesenteric and peripheral lymph nodes in double mutant mice is dramatically decreased to ~25% of that in wild-type
• number of lymphocytes in peripheral lymph nodes is decreased to 40% relative to wild-type
impaired leukocyte tethering or rolling ( J:113195 )
• GlyCAM-1 from double mutant mice supports the least rolling of wild-type lymphocytes

hematopoietic system
abnormal leukocyte migration ( J:113195 )
• lymphocyte homing to mesenteric and peripheral lymph nodes in double mutant mice is dramatically decreased to ~25% of that in wild-type
• number of lymphocytes in peripheral lymph nodes is decreased to 40% relative to wild-type
impaired leukocyte tethering or rolling ( J:113195 )
• GlyCAM-1 from double mutant mice supports the least rolling of wild-type lymphocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory