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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ms4a2tm1Knt
targeted mutation 1, Jean-Pierre Kinet
MGI:3664659
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ms4a2tm1Knt/Ms4a2tm1Knt involves: 129 * BALB/c MGI:3703596
cx2
 		Ms4a2tm1Knt/Ms4a2tm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0 		involves: 129 * BALB/c MGI:3703595


Genotype
MGI:3703596
hm1
Allelic
Composition		 Ms4a2tm1Knt/Ms4a2tm1Knt
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ms4a2tm1Knt mutation (1 available); any Ms4a2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:47138 )
• after stimulation with 2.4G2, very little bone marrow mast cell degranulation is observed
decreased susceptibility to type I hypersensitivity reaction ( J:47138 )
• injection of 2.4G2 to induce anaphylaxis results in a smaller decrease in rectal temperature ( 2 degrees) compared to Fcer1a-deficient mice (8 degrees) or wild-type mice (4 degrees)
abnormal cytokine secretion ( J:47138 )
• Il-6 production in stimulated BMMCs is reduced compared to Fcer1a-null mice

hematopoietic system
abnormal mast cell physiology ( J:47138 )
• after stimulation with 2.4G2, very little bone marrow mast cell degranulation is observed




Genotype
MGI:3703595
cx2
Allelic
Composition		 Ms4a2tm1Knt/Ms4a2tm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ms4a2tm1Knt mutation (1 available); any Ms4a2 mutation (12 available)
Tg(SV40/HTLV-FCER1A)1Bhk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:47138 )
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice
decreased susceptibility to type I hypersensitivity reaction ( J:47138 )
• mice show a weaker response (temperature drop) in a model of anaphlaxis (injections of IgE every 12 hours for 36 hours, then antigenic challenge)
abnormal cytokine secretion ( J:47138 )
• Il-6 production in stimulated BMMCs is reduced compared to Ms4a2-heterozygous transgenic mice

hematopoietic system
abnormal mast cell physiology ( J:47138 )
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory