Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mr1tm1Gfn mutation
(2 available);
any
Mr1 mutation
(26 available)
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immune system
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• mice have a significantly more severe form of EAE with an earlier onset than controls after induction with MOG peptide
• mean day of onset is 11.5 compared to 13.9 for wild-type controls
• mean severity score is 4.0 versus 3.0 in wild-type controls
• memory T cells isolated from mice 10 days after disease induction proliferate more and produce more TH-1 cytokines and less IL-10
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mr1tm1Gfn mutation
(2 available);
any
Mr1 mutation
(26 available)
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immune system
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• L. longbeachae-infected mice fail to exhibit an increase in atypical MR1 tetramer-reactive cells in the lungs compared with wild-type mice
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Allelic
Composition |
Mr1tm1Gfn/Mr1tm1Gfn
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Genetic
Background |
involves: 129P2/OlaHsd * BALB/c * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mr1tm1Gfn mutation
(2 available);
any
Mr1 mutation
(26 available)
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|
|
immune system
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• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
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• preliminary results indicate a reduction in the number of IgA producing B cells in the gut
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hematopoietic system
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• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
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• preliminary results indicate a reduction in the number of IgA producing B cells in the gut
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Analysis Tools