All Phenotypes Klhl1/Atxn8os<tm1Mdk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Klhl1/Atxn8os^tm1Mdk
targeted mutation 1, Michael D Koob
MGI:3664538

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Klhl1/Atxn8os^tm1Mdk/Klhl1/Atxn8os^tm1Mdk Tg(Pcp2-cre)3Mdk/0	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	MGI:3689862

Allelic Composition	Klhl1/Atxn8os^tm1Mdk/Klhl1/Atxn8os^tm1Mdk Tg(Pcp2-cre)3Mdk/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klhl1/Atxn8os^tm1Mdk mutation (0 available); any Klhl1 mutation (51 available)
Tg(Pcp2-cre)3Mdk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:112937 )

• loss of motor coordination at 24 weeks of age in a rotarod test

nervous system

thin cerebellar molecular layer ( J:112937 )

• layer normal at 6 weeks but definitely thinner at 24 weeks of age

• dendritic atrophy of Purkinje cells seen but Purkinje cells themselves display an overall normal morphology

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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