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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnip2tm1.1Sley
targeted mutation 1.1, Steven C Ley
MGI:3664444
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnip2tm1.1Sley/Tnip2tm1.1Sley involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 MGI:3710363


Genotype
MGI:3710363
hm1
Allelic
Composition		 Tnip2tm1.1Sley/Tnip2tm1.1Sley
Genetic
Background		 involves: 129S4/SvJae * 129S8/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnip2tm1.1Sley mutation (0 available); any Tnip2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:112395 )
N
• mice show no developmental abnormalities of T cell or B cell lineage and numbers of macrophages and dendritic cells in the spleen is similar to those in wild-type
abnormal macrophage physiology ( J:112395 )
• Erk phosphorylation induced by TLR2, 3, and 9 ligands is much less

hematopoietic system
abnormal macrophage physiology ( J:112395 )
• Erk phosphorylation induced by TLR2, 3, and 9 ligands is much less




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory