Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Agtr1a)4-7Vjd
• Allele Name: transgene insertion 4-7, Victor J Dzau
• Allele ID: MGI:3664306
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Agtr1a)4-7Vjd/0	FVB/N-Tg(Myh6-Agtr1a)4-7Vjd	MGI:3664307

Genotype
MGI:3664307

tg1

• Allelic Composition: Tg(Myh6-Agtr1a)4-7Vjd/0
• Genetic Background: FVB/N-Tg(Myh6-Agtr1a)4-7Vjd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:40974 )

• most die in utero (between E16-19) or immediately after birth

cardiovascular system

increased heart atrium size ( J:40974 )

• massive enlargement of the atria is detectable at E16-19, with atria almost as big as the ventricles

• increase in atrial size is due to hyperplasia of atrial myocytes

increased heart weight ( J:40974 )

• heart weight and heart-to-body-weight ratio is increased 2.14-fold and 2.28-fold due to increase in atrial mass

heart hyperplasia ( J:40974 )

• myocyte hyperplasia leading to massive atrial enlargement

decreased heart rate ( J:40974 )

• newborns under anesthesia have a significantly lower heart rate than controls

abnormal impulse conducting system conduction ( J:40974 )

atrioventricular block ( J:40974 )

prolonged PR interval ( J:40974 )

• exhibit atrioventricular conduction block, as evidenced by a significant prolongation of the PR interval

prolonged QRS complex duration ( J:40974 )

• exhibit widening of the QRS complex, suggesting a decrease in conduction velocity in the ventricles

growth/size/body

increased heart weight ( J:40974 )

• heart weight and heart-to-body-weight ratio is increased 2.14-fold and 2.28-fold due to increase in atrial mass

heart hyperplasia ( J:40974 )

• myocyte hyperplasia leading to massive atrial enlargement