Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actg1tm1.1Erv mutation
(0 available);
any
Actg1 mutation
(23 available)
Actg1tm1Erv mutation
(0 available);
any
Actg1 mutation
(23 available)
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hearing/vestibular/ear
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• reduction in stereocilia numbers is similar to Actg1tm1.1Erv homozygotes
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• marked hearing loss by 28 weeks of age
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nervous system
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• reduction in stereocilia numbers is similar to Actg1tm1.1Erv homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actg1tm1Erv mutation
(0 available);
any
Actg1 mutation
(23 available)
Tg(ACTA1-cre)79Jme mutation
(2 available)
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behavior/neurological
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• about 2/3 of mice show classical hind limb contractures when suspended by the tail
• persists throughout life without getting any worse
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• reduced mobility
• persists throughout life without getting any worse
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muscle
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• dystrophin is less organized at the z-line in some muscles
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• muscles primarily made up of type II fibers are most affected
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• more variability in muscle fiber size
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• centrally nucleated fibers start appearing in muscle at about 3 months of age and progress to widespread incidence by 12 to 18 months
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• maximal force production by extensor digitorum longus muscle is less than in controls
• maximal titanic force is similar to controls
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