Phenotypes associated with this allele

• Allele Symbol: Sumo1^{Gt(RRQ016)Byg}
• Allele Name: gene trap RRQ016, BayGenomics
• Allele ID: MGI:3664241
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sumo1^Gt(RRQ016)Byg/Sumo1^Gt(RRQ016)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3712504
ht2	Sumo1^Gt(RRQ016)Byg/Sumo1^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3712503
cx3	Eya1^tm1Rilm/Eya1^+ Sumo1^Gt(RRQ016)Byg/Sumo1^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3712507

Genotype
MGI:3712504

hm1

• Allelic Composition: Sumo1^{Gt(RRQ016)Byg}/Sumo1^{Gt(RRQ016)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:112841 )

• a level of embryonic death is noted between E13.5 and E18.5

• genotypic distribution at P1 differs from expected 1:2:1

neonatal lethality, incomplete penetrance ( J:112841 )

• immediate postnatal death is observed with some pups

• genotypic distribution at P1 differs from expected 1:2:1

normal phenotype

no abnormal phenotype detected ( J:141678 )

• contrary to an earlier report, homozygous mice display no abnormal phenotype

Genotype
MGI:3712503

ht2

• Allelic Composition: Sumo1^{Gt(RRQ016)Byg}/Sumo1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:112841 )

• a level of embryonic death is noted between E13.5 and E18.5

• genotypic distribution at P1 differs from expected 1:2:1

neonatal lethality, incomplete penetrance ( J:112841 )

• immediate postnatal death is observed with some pups

• genotypic distribution at P1 differs from expected 1:2:1

normal phenotype

no abnormal phenotype detected ( J:141678 )

• contrary to an earlier report, heterozygous mice display no abnormal phenotype

craniofacial

cleft secondary palate ( J:112841 )

• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft

oblique facial cleft ( J:112841 )

• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft

digestive/alimentary system

cleft secondary palate ( J:112841 )

• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft

growth/size/body

cleft secondary palate ( J:112841 )

• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft

oblique facial cleft ( J:112841 )

• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft

Genotype
MGI:3712507

cx3

• Allelic Composition: Eya1^tm1Rilm/Eya1⁺; Sumo1^{Gt(RRQ016)Byg}/Sumo1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

craniofacial

cleft secondary palate ( J:112841 )

• cleft palate occurs with 36% frequency (4/11 heterozygotes) compared to 8.7% in Sumo1 single heterozygotes

digestive/alimentary system

cleft secondary palate ( J:112841 )

• cleft palate occurs with 36% frequency (4/11 heterozygotes) compared to 8.7% in Sumo1 single heterozygotes

growth/size/body

cleft secondary palate ( J:112841 )

• cleft palate occurs with 36% frequency (4/11 heterozygotes) compared to 8.7% in Sumo1 single heterozygotes