Phenotypes associated with this allele

• Allele Symbol: Cytip^tm1Tes
• Allele Name: targeted mutation 1, Lino Tessarollo
• Allele ID: MGI:3664082
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cytip^tm1Tes/Cytip^tm1Tes	involves: 129S1/Sv * FVB/N	MGI:3715244

Genotype
MGI:3715244

hm1

• Allelic Composition: Cytip^tm1Tes/Cytip^tm1Tes
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:110320 )

• deficient splenocytes injected into wild-type recipients which overexpress Th1 cytokines show lower efficiency in migrating to the spleen

• in a model of aseptic peritonitis, seven days after peritonitis induction, mutants have lower numbers of inflammatory cells in the peritoneal cavity compared to wild-type mice

abnormal cellular extravasation ( J:110320 )

• in an aseptic peritonitis model, neutrophils display a defect in exiting the circulation into the peritoneal cavity; neutrophils are present in greater numbers in circulation of mutant animals compared to wild-type in aseptic peritonitis model

• after induction of peritonitis in Pscdbp-deficient mice, a limited reduction in circulating WBCs is observed compared to a 50% decrease in wild-type controls

decreased leukocyte cell number ( J:110320 )

• reduced circulating WBCs in animals >6 months of age, with reduction of neutrophilic and monocytic fractions

decreased lymphocyte cell number ( J:110320 )

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:110320 )

• reduced numbers of virus specific CTLs are observed infiltrating the tumors in null mice

lymph node hypoplasia ( J:110320 )

• lymphocyte numbers in tumor-draining lymph nodes are significantly reduced compared to controls mice, with fewer leukocytes infiltrating the tumors

hematopoietic system

abnormal leukocyte migration ( J:110320 )

• deficient splenocytes injected into wild-type recipients which overexpress Th1 cytokines show lower efficiency in migrating to the spleen

• in a model of aseptic peritonitis, seven days after peritonitis induction, mutants have lower numbers of inflammatory cells in the peritoneal cavity compared to wild-type mice

abnormal cellular extravasation ( J:110320 )

• in an aseptic peritonitis model, neutrophils display a defect in exiting the circulation into the peritoneal cavity; neutrophils are present in greater numbers in circulation of mutant animals compared to wild-type in aseptic peritonitis model

• after induction of peritonitis in Pscdbp-deficient mice, a limited reduction in circulating WBCs is observed compared to a 50% decrease in wild-type controls

decreased leukocyte cell number ( J:110320 )

• reduced circulating WBCs in animals >6 months of age, with reduction of neutrophilic and monocytic fractions

decreased lymphocyte cell number ( J:110320 )

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:110320 )

• reduced numbers of virus specific CTLs are observed infiltrating the tumors in null mice

neoplasm

increased sarcoma incidence ( J:110320 )

• in null mice injected with Moloney murine sarcoma/Moloney murine leukemia virus, a higher (but nonsignificant) levelo of tumor incidence is observed (87% vs 70% in controls); mutant animals develop significantly larger sarcomas than wild-type mice

• regression of tumors occurs with slower kinetics than in wild-type controls

cellular

abnormal leukocyte migration ( J:110320 )

• deficient splenocytes injected into wild-type recipients which overexpress Th1 cytokines show lower efficiency in migrating to the spleen

• in a model of aseptic peritonitis, seven days after peritonitis induction, mutants have lower numbers of inflammatory cells in the peritoneal cavity compared to wild-type mice

abnormal cellular extravasation ( J:110320 )

• in an aseptic peritonitis model, neutrophils display a defect in exiting the circulation into the peritoneal cavity; neutrophils are present in greater numbers in circulation of mutant animals compared to wild-type in aseptic peritonitis model

• after induction of peritonitis in Pscdbp-deficient mice, a limited reduction in circulating WBCs is observed compared to a 50% decrease in wild-type controls