Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Lef1)2Tfo
• Allele Name: transgene insertion 2, Thomas Force
• Allele ID: MGI:3664022
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Lef1)2Tfo/Y	involves: C57BL/6J * FVB/N	MGI:3664023
tg2	Tg(Myh6-Lef1)2Tfo/0	involves: C57BL/6J * FVB/N	MGI:3664025

Genotype
MGI:3664023

tg1

• Allelic Composition: Tg(Myh6-Lef1)2Tfo/Y
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:109612 )

♂ • very few males survive to birth and none survive for more than 1 to 2 days

Genotype
MGI:3664025

tg2

• Allelic Composition: Tg(Myh6-Lef1)2Tfo/0
• Genetic Background: involves: C57BL/6J * FVB/N

cardiovascular system

decreased heart left ventricle posterior wall thickness ( J:109612 )

• left ventricular posterior wall thickness is reduced by an average of 22%

dilated heart left ventricle ( J:109612 )

dilated heart right ventricle ( J:109612 )

dilated cardiomyopathy ( J:109612 )

• ventricles are dilated with depressed contractile function, consistent with severe dilated cardiomyopathy

decreased heart ventricle muscle contractility ( J:109612 )

increased heart rate ( J:109612 )

abnormal myocardial fiber physiology ( J:109612 )

• cardiomyocytes exhibit limited ability to undergo concentric hypertrophy

muscle

dilated cardiomyopathy ( J:109612 )

• ventricles are dilated with depressed contractile function, consistent with severe dilated cardiomyopathy

decreased heart ventricle muscle contractility ( J:109612 )