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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lin9tm1Orc
targeted mutation 1, Oscar R Colamonici
MGI:3663755
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lin9tm1Orc/Lin9tm1Orc Not Specified MGI:3712955
cx2
 		Cdk4tm1Kiyo/Cdk4tm1Kiyo
Lin9tm1Orc/Lin9tm1Orc 		involves: 129S1/Sv MGI:3712953
cx3
 		Cdk4tm1Kiyo/Cdk4+
Lin9tm1Orc/Lin9+ 		involves: 129S1/Sv MGI:3712956


Genotype
MGI:3712955
hm1
Allelic
Composition		 Lin9tm1Orc/Lin9tm1Orc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin9tm1Orc mutation (0 available); any Lin9 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:111333 )




Genotype
MGI:3712953
cx2
Allelic
Composition		 Cdk4tm1Kiyo/Cdk4tm1Kiyo
Lin9tm1Orc/Lin9tm1Orc
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1Kiyo mutation (0 available); any Cdk4 mutation (57 available)
Lin9tm1Orc mutation (0 available); any Lin9 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
female infertility ( J:111333 )
• 50% of females are infertile
male infertility ( J:111333 )
• 10% of mice are infertile

endocrine/exocrine glands
adenohypophysis hypoplasia ( J:111333 )
• anterior pituitary cellularity is reduced (2.7x105 compared to 2.2x106 in wild-type mice)

growth/size/body
decreased body weight ( J:111333 )
• mice are smaller than normal but larger than Cdk4tm1Kiyo homozygotes

cellular
abnormal cell cycle ( J:111333 )
• number of MEF cells in S-phase is increased by almost 5-fold

nervous system
adenohypophysis hypoplasia ( J:111333 )
• anterior pituitary cellularity is reduced (2.7x105 compared to 2.2x106 in wild-type mice)




Genotype
MGI:3712956
cx3
Allelic
Composition		 Cdk4tm1Kiyo/Cdk4+
Lin9tm1Orc/Lin9+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1Kiyo mutation (0 available); any Cdk4 mutation (57 available)
Lin9tm1Orc mutation (0 available); any Lin9 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:111333 )
• number of MEF cells in S-phase is increased by 2.3-fold

immune system
decreased susceptibility to autoimmune diabetes ( J:111333 )
• mice do not develop early onset diabetes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory