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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cd8b1)46Erob
transgene insertion 46, Ellen Robey
MGI:3663518
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cd8b1tm1Litt/Cd8b1+
Tg(Cd8b1)46Erob/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:3665228
tg2
 		Tg(Cd8b1)46Erob/0 involves: 129S4/SvJae * C57BL/6 * CBA MGI:3665229


Genotype
MGI:3665228
cx1
Allelic
Composition		 Cd8b1tm1Litt/Cd8b1+
Tg(Cd8b1)46Erob/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8b1tm1Litt mutation (1 available); any Cd8b1 mutation (20 available)
Tg(Cd8b1)46Erob mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell subpopulation ratio ( J:110916 )
• CD8 to CD4 ratio is 2.2-fold lower than in wild-type
decreased T cell number ( J:110916 )
• there is a lack of mature CD8-lineage T cells
decreased thymocyte number ( J:110916 )
• mice have 3-fold fewer CD8-lineage thymocytes compared to wild-type

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:110916 )
• thymocytes display 4-fold less CD8-associated Lck activity vs wild-type
• activity of Lck is reduced but significant levels are detected in mutants; there is a slight reduction in CD8a-associated activity compared to wild-type

hematopoietic system
abnormal T cell subpopulation ratio ( J:110916 )
• CD8 to CD4 ratio is 2.2-fold lower than in wild-type
decreased T cell number ( J:110916 )
• there is a lack of mature CD8-lineage T cells
decreased thymocyte number ( J:110916 )
• mice have 3-fold fewer CD8-lineage thymocytes compared to wild-type

endocrine/exocrine glands
decreased thymocyte number ( J:110916 )
• mice have 3-fold fewer CD8-lineage thymocytes compared to wild-type




Genotype
MGI:3665229
tg2
Allelic
Composition		 Tg(Cd8b1)46Erob/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell subpopulation ratio ( J:110916 )
• CD8 to CD4 ratio is 1.8 fold lower than in wild-type
decreased T cell number ( J:110916 )
• there is a lack of mature CD8-lineage T cells
decreased thymocyte number ( J:110916 )
• mice have 2-fold fewer CD8-lineage thymocytes compared to wild-type; there is a lack of mature CD8-lineage T cells

hematopoietic system
abnormal T cell subpopulation ratio ( J:110916 )
• CD8 to CD4 ratio is 1.8 fold lower than in wild-type
decreased T cell number ( J:110916 )
• there is a lack of mature CD8-lineage T cells
decreased thymocyte number ( J:110916 )
• mice have 2-fold fewer CD8-lineage thymocytes compared to wild-type; there is a lack of mature CD8-lineage T cells

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:110916 )
• thymocytes show 2-fold reduction in CD8-associated Lck activity vs wild-type
• activity of Lck is reduced but significant levels are detected in mutants; there is a slight reduction in CD8a-associated activity compared to wild-type

endocrine/exocrine glands
decreased thymocyte number ( J:110916 )
• mice have 2-fold fewer CD8-lineage thymocytes compared to wild-type; there is a lack of mature CD8-lineage T cells




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory