Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-TEAD4)3Afrs
• Allele Name: transgene insertion 3, Alexandre F R Stewart
• Allele ID: MGI:3663411
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-TEAD4)3Afrs/0	involves: FVB	MGI:3663752

Genotype
MGI:3663752

tg1

• Allelic Composition: Tg(Myh6-TEAD4)3Afrs/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:112740 )

• many die suddenly around 10 months of age

cardiovascular system

dilated heart atrium ( J:112740 )

• develop atrial dilatation by 4 months of age without atrial or ventricular myocardial hypertrophy

increased heart rate ( J:112740 )

• 4-6 month old mutants exhibit spontaneous transient episodes of supraventricular tachyarrhythmias

irregular heartbeat ( J:112740 )

• 4-6 month old mutants exhibit spontaneous transient episodes of supraventricular tachyarrhythmias

atrial fibrillation ( J:112740 )

• by 12 months of age, nearly all (7 of 8) mutants appear to be in sustained atrial fibrillation

abnormal impulse conducting system conduction ( J:112740 )

• exhibit slower conduction over the surface of the atrial and ventricular myocardium

• significant prolongation of the AH interval but not the HV interval, suggesting a conduction delay above the bundle of His

• conduction defects are correlated with dephosphorylation of Gja5 (connexin40) and Gja1 (connexin43) and upregulation of protein phosphatase 1 beta, suggesting that defective conduction is a result of impaired gap-junction conductance rather than assembly

prolonged PR interval ( J:112740 )

• surface and intracardiac ECGs reveal prolongation of the PR interval

prolonged QRS complex duration ( J:112740 )

• surface and intracardiac ECGs reveal prolongation of QRS duration

homeostasis/metabolism

abnormal atrial thrombosis ( J:112740 )

• many mutants show severe thrombosis by 10 months of age