Phenotypes associated with this allele

• Allele Symbol: Gata6^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:3663288
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata6^tm1Eno/Gata6^tm1Eno	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)	MGI:3663412
cx2	Gata4^tm1Eno/Gata4^+ Gata6^tm1Eno/Gata6^+	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6	MGI:3663413

Genotype
MGI:3663412

hm1

• Allelic Composition: Gata6^tm1Eno/Gata6^tm1Eno
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:111824 )

• no homozygotes are observed after E7.5

embryo

abnormal visceral endoderm morphology ( J:111824 )

• failure in visceral endoderm differentiation

Genotype
MGI:3663413

cx2

• Allelic Composition: Gata4^tm1Eno/Gata4⁺; Gata6^tm1Eno/Gata6⁺
• Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:111824 )

• lethality by E13.5

cardiovascular system

abnormal blood vessel morphology ( J:111824 )

• cranial and intersomitic vasculature is enlarged and disorganized at E10.5

• exhibit thin and dilated vessels

abnormal aorta morphology ( J:111824 )

aortic arch hypoplasia ( J:111824 )

• hypoplastic transcending aortic arch

aorta hypoplasia ( J:111824 )

• hypoplastic aorta at E12.5

dilated aorta ( J:111824 )

• dilated aorta at E12.5

abnormal vascular smooth muscle morphology ( J:111824 )

• show a reduction in the arterial smooth muscle

abnormal aorta smooth muscle morphology ( J:111824 )

• at E12.5, mutants show less smooth muscle in the medial layer of the aorta

thin myocardium compact layer ( J:111824 )

• hearts at E13.5 contain only two myocardial cell layers within the compact zone instead of the normal five layers

thin myocardium ( J:111824 )

• myocardial thinning becomes apparent at E12.5

abnormal cardiac outflow tract development ( J:111824 )

• exhibit patterning defects of the outflow tract at E12

persistent truncus arteriosus ( J:111824 )

• seen at E12, resulting from incomplete septation of the conotruncus into the aorta and pulmonary artery

abnormal interventricular septum morphology ( J:111824 )

• exhibit a modest delay in the formation of the ventricular septum beginning at E11.5

ventricular septal defect ( J:111824 )

• show ventricular septal defects that persist until death

hemorrhage ( J:111824 )

• display widespread hemorrhages by E11.5

decreased fetal cardiomyocyte proliferation ( J:111824 )

• display reduced cardiomyocyte proliferation at E10.5

irregular heartbeat ( J:111824 )

• heartbeat at E11.75 is sluggish and irregular

hematopoietic system

decreased erythrocyte cell number ( J:111824 )

• reduction in the number of mature erythrocytes in peripheral blood

homeostasis/metabolism

edema ( J:111824 )

• display edema at E13.5

liver/biliary system

small liver ( J:111824 )

muscle

abnormal vascular smooth muscle morphology ( J:111824 )

• show a reduction in the arterial smooth muscle

abnormal aorta smooth muscle morphology ( J:111824 )

• at E12.5, mutants show less smooth muscle in the medial layer of the aorta

thin myocardium compact layer ( J:111824 )

• hearts at E13.5 contain only two myocardial cell layers within the compact zone instead of the normal five layers

thin myocardium ( J:111824 )

• myocardial thinning becomes apparent at E12.5

decreased fetal cardiomyocyte proliferation ( J:111824 )

• display reduced cardiomyocyte proliferation at E10.5

cellular

decreased fetal cardiomyocyte proliferation ( J:111824 )

• display reduced cardiomyocyte proliferation at E10.5