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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ins2-Fas*I246N)1Ach
transgene insertion 1, Alexander V Chervonsky
MGI:3662920
Summary 2 genotypes


Genotype
MGI:3663041
cx1
Allelic
Composition		 Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0
Genetic
Background		 NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Fas*I246N)1Ach mutation (1 available)
Tg(Ins2-Fasl)24Ach mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:81416 )
• double transgenics show slower onset of diabetes compared to NOD-Tg(Ins2-Fasl)24Ach single transgenics

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:81416




Genotype
MGI:3663020
tg2
Allelic
Composition		 Tg(Ins2-Fas*I246N)1Ach/0
Genetic
Background		 NOD-Tg(Ins2-Fas*I246N)1Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Fas*I246N)1Ach mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:81416 )
• transgenic mice show some level of protection against spontaneous diabetes, correlating with level of transgene expression
• onset of diabetes in slightly delayed in mice injected with diabetic T cells compared to NOD controls (16 days vs 13 days) or Fasl transgenic mice (16 days vs 5 days)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory