Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1ffe mutation
(1 available);
any
Slc40a1 mutation
(53 available)
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mortality/aging
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• mid-gestational lethality
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hematopoietic system
homeostasis/metabolism
nervous system
N |
• Background Sensitivity: no neural tube defects are seen in mice crossed onto a 129X1/SvJ background, unlike mice on a mixed background including C3H/HeJ
• Background Sensitivity: forebrain truncations are not seen in mice crossed onto a 129X1/SvJ background, unlike mice on a mixed background including C3H/HeJ
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vision/eye
N |
• Background Sensitivity: microphthalmia is not seen in mice crossed onto a 129X1/SvJ background, unlike mice on a mixed background including C3H/HeJ
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1ffe mutation
(1 available);
any
Slc40a1 mutation
(53 available)
|
|
|
mortality/aging
|
• mid-gestational lethality
|
hematopoietic system
homeostasis/metabolism
nervous system
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• Background Sensitivity: neural tube closure defects are seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background
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• Background Sensitivity: forebrain truncations are seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background
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vision/eye
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• Background Sensitivity: microphthalmia is seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background
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embryo
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• Background Sensitivity: neural tube closure defects are seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background
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Allelic Composition |
Slc40a1ffe/Slc40a1+
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Genetic Background |
either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1ffe mutation
(1 available);
any
Slc40a1 mutation
(53 available)
|
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|
homeostasis/metabolism
hematopoietic system
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• some hypochromic red cells are present in blood smears
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• some hypochromic red cells with variable size are present in blood smears
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• some target cells are present in blood smears
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• iron loaded macrophages are not able to export iron as efficiently as wild-type cells
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immune system
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• iron loaded macrophages are not able to export iron as efficiently as wild-type cells
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liver/biliary system
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• aged mice accumulate high levels of iron in Kupffer cells
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