Analysis Tools
hematopoietic system
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• a defect in B cell maturation similar to that in Tg(Igh-6-Cd80)1Gjf mice is observed
• 3 week old transgenics have fewer B cells than wild-type mice; percentage of B cells in the spleens of young wild-type is 54% vs 25% in transgenics
• adult mice have comparable numbers of B cells in the spleens
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• transgene expressing T cells can be activated by anti-CD3 alone, whereas wild-type T cells require presence of costimulatory signals for activation
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immune system
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• a defect in B cell maturation similar to that in Tg(Igh-6-Cd80)1Gjf mice is observed
• 3 week old transgenics have fewer B cells than wild-type mice; percentage of B cells in the spleens of young wild-type is 54% vs 25% in transgenics
• adult mice have comparable numbers of B cells in the spleens
|
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• transgene expressing T cells can be activated by anti-CD3 alone, whereas wild-type T cells require presence of costimulatory signals for activation
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