Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Mom mutation
(12 available);
any
Tcrb mutation
(94 available)
Tg(H2-K-Cd86)7All mutation
(0 available)
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hematopoietic system
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• mice have same numbers of B cells in spleen and lymph nodes as control littermates
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• transgenic B cells increase in size and show upregulated MHC class II when mice are injected with T cells
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• mice show a substantial decrease in B220+ cells in bone marrow when mice receive nontransgenic T cells
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• when syngeneic wild-type T cells are transferred into Tcrb-deficient transgenic hosts, after 3 weeks the number of B cells in peripheral lymphoid tissues is decreased by ~50% compared with Tcrb-deficient mice not injected with T cells
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immune system
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• transgenic B cells increase in size and show upregulated MHC class II when mice are injected with T cells
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• mice show a substantial decrease in B220+ cells in bone marrow when mice receive nontransgenic T cells
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• when syngeneic wild-type T cells are transferred into Tcrb-deficient transgenic hosts, after 3 weeks the number of B cells in peripheral lymphoid tissues is decreased by ~50% compared with Tcrb-deficient mice not injected with T cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Mak mutation
(12 available);
any
Cd28 mutation
(53 available)
Tg(H2-K-Cd86)7All mutation
(0 available)
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hematopoietic system
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• compared to wild-type Cd28 transgenic mice Cd28-deficient mice show no lymphocyte expansion or increase in CD8+ T cell population
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immune system
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• compared to wild-type Cd28 transgenic mice Cd28-deficient mice show no lymphocyte expansion or increase in CD8+ T cell population
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
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• there is a decreased proportion of B cells in the spleens compared to controls
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• a similarly small but significant decrease in percentage of single positive CD4 thymocytes is observed
• in the spleen there is a lower percentage of CD4+ T cells that is more evident than in the thymus
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• in the spleens there is an increase in T cell number
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• a small but significant increase in percentage of single-positive CD8 thymocytes is seen compared to controls
• in the spleen there is a higher percentage of CD8+ T cells that is more evident than in the thymus
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• in peripheral lymph nodes, there is a significant lymphocyte expansion with lymph node cells increased >6-fold over littermate controls
• Background Sensitivity: on a B6 congenic background peripheral lymphocyte proliferation is lower compared to that on a (BALB/c x C57BL/6)F1 background
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• expression of the Cd86 transgene results in hyperplasia of peripheral lymphoid organs
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• there is extensive lymphoid infiltration of other organs including the lungs
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hematopoietic system
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• there is a decreased proportion of B cells in the spleens compared to controls
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• a similarly small but significant decrease in percentage of single positive CD4 thymocytes is observed
• in the spleen there is a lower percentage of CD4+ T cells that is more evident than in the thymus
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• in the spleens there is an increase in T cell number
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• a small but significant increase in percentage of single-positive CD8 thymocytes is seen compared to controls
• in the spleen there is a higher percentage of CD8+ T cells that is more evident than in the thymus
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Allelic
Composition |
Tg(H2-K-Cd86)7All/0
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Genetic
Background |
involves: BALB/c * C57BL/6 * CBA |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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hematopoietic system
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• number of splenocytes is increased by >200-fold
• on a (BALB/c x C57BL/6)F1 background peripheral lymphocyte proliferation is greater with splenocyte numbers compared to a coisogenic B6 background
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• number of splenocytes is increased by >200-fold
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immune system
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• number of splenocytes is increased by >200-fold
• on a (BALB/c x C57BL/6)F1 background peripheral lymphocyte proliferation is greater with splenocyte numbers compared to a coisogenic B6 background
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• number of splenocytes is increased by >200-fold
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• in peripheral lymph nodes, there is a significant lymphocyte expansion with lymph node cells increased >10-fold over littermate controls
• Background Sensitivity: on a (BALB/c x C57BL/6)F1 background peripheral lymphocyte proliferation is greater compared to a coisogenic B6 background
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growth/size/body
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• number of splenocytes is increased by >200-fold
• on a (BALB/c x C57BL/6)F1 background peripheral lymphocyte proliferation is greater with splenocyte numbers compared to a coisogenic B6 background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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hematopoietic system
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• proportion of pre/pro B cells and immature/mature B cells is low in bone marrow in transgenic mice
• B cells are slightly larger than wild-type
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• some mice expressing transgene at high levels show substantial reduction in B lymphocytes in all peripheral tissues; some mice exhibit a severe reduction in number in spleen with an increase in number the lymph nodes
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• numbers of CD4+ T cells are increased in the spleen but not in lymph nodes of mice; an increased fraction of and T cells are CD44hi
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• numbers of CD8+ T cells are increased in the spleen but not in lymph nodes of mice; an increased fraction of CD8+ cells are CD44hi
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immune system
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• proportion of pre/pro B cells and immature/mature B cells is low in bone marrow in transgenic mice
• B cells are slightly larger than wild-type
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• some mice expressing transgene at high levels show substantial reduction in B lymphocytes in all peripheral tissues; some mice exhibit a severe reduction in number in spleen with an increase in number the lymph nodes
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• numbers of CD4+ T cells are increased in the spleen but not in lymph nodes of mice; an increased fraction of and T cells are CD44hi
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• numbers of CD8+ T cells are increased in the spleen but not in lymph nodes of mice; an increased fraction of CD8+ cells are CD44hi
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Analysis Tools