All Phenotypes Gadd45g<tm1Mhol> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gadd45g^tm1Mhol/Gadd45g^tm1Mhol	involves: 129	MGI:3653938
hm2	Gadd45g^tm1Mhol/Gadd45g^tm1Mhol	involves: C57BL/6N	MGI:5461350
cx3	Gadd45a^tm1Ajf/Gadd45a^tm1Ajf Gadd45b^tm1Daa/Gadd45b^tm1Daa Gadd45g^tm1Mhol/Gadd45g^tm1Mhol	either: (involves: 129X1/SvJ) or (involves: 129P2/OlaHsd * 129X1/SvJ)	MGI:3653937

Allelic Composition	Gadd45g^tm1Mhol/Gadd45g^tm1Mhol
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45g^tm1Mhol mutation (0 available); any Gadd45g mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:110650 )

• confluent 2nd passage renal medullary cells show reduced viability in when stressed by NaCl or urea at 1240 mosmol/kg water compared to wild-type cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal testis development ( J:191095 )

• at E14.5 XY gonads are smaller compared to wild-type controls

• expression analysis indicates early male gonad specification is permanently interrupted in XY gonads

absent testis cords ( J:191095 )

• at E14.5 XY gonads lack testis cords

primary sex reversal ( J:191095 )

• male to female sex reversal with internal reproductive organs in XY mice closely resembling those in XX mice

• ovaries and uteri are comparable in size and shape in XY and XX mice

• only 3.5% of homozygous mice are phenotypically male but the expected percentage of XY mice are found

secondary sex reversal ( J:191095 )

• male to female sex reversal with external genitalia in XY mice closely resembling those in XX mice

infertility ( J:191095 )

• XY females are infertile; however, XX females are fertile

endocrine/exocrine glands