Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Rha mutation
(4 available);
any
Efnb1 mutation
(15 available)
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mortality/aging
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• about 10% of mice die within 24 hours of birth
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craniofacial
digestive/alimentary system
growth/size/body
Allelic
Composition |
Efnb1tm1Rha/Efnb1+
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Genetic
Background |
involves: 129P2/OlaHsd |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Rha mutation
(4 available);
any
Efnb1 mutation
(15 available)
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skeleton
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• fusion occurs in 1 of 7 mice
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limbs/digits/tail
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• 10% of mice have preaxial polydactyly
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Rha mutation
(4 available);
any
Efnb1 mutation
(15 available)
Tg(Pgk1-cre)1Lni mutation
(1 available)
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mortality/aging
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• only 15% of expected males reach weaning
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reproductive system
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N |
• the few surviving males are fertile
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limbs/digits/tail
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• at E12, extra cartilaginous elements are present
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• ectopic ossifications form in 4 of 5 adults typically in the posterior limbs and either attached to or in close proximity to triquatral and harnate bone
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• distal carpal bones are fused
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• almost exclusively of digits I or II and often associated with syndactyly
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skeleton
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• ectopic ossifications form in 4 of 5 adults typically in the posterior limbs and either attached to or in close proximity to triquatral and harnate bone
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• distal carpal bones are fused
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• at E15.5, 2 sternal bands are incomplete
• condensing mesenchyme (collagen2a+) in sternal bands is diffuse and poorly delineated
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• sternebra are fused in 6 of 11 mice
• ossification centers for sternal segments are expanded and fused regardless of proper rib pairing
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• at E18.5, 5 of 11 mice have asymmetric rib pairing
• sternocostal junctions are abnormally positioned and fused in 6 of 11 mice
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• cartilages corresponding to the distal carpal bones are delayed or sometimes impaired
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• ossification centers in the ribs for sternal segments are expanded and fused in 6 of 11 mice
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craniofacial
homeostasis/metabolism
digestive/alimentary system
growth/size/body
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• at E14.5, the body wall is incompletely closed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Rha mutation
(4 available);
any
Efnb1 mutation
(15 available)
Tg(Pgk1-cre)1Lni mutation
(1 available)
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|
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mortality/aging
|
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• only 1-2% of females survived past weaning
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skeleton
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• ectopic ossifications form in 1 of 5 adults
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• distal carpal bones are fused
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• at E18.5, in 3 of 8 mice and to a lesser extent than in hemizygous Efnb1tm1Rha Tg(Pgk1-cre)1Lni males
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• cartilages corresponding to the distal carpal bones are delayed or sometimes impaired
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limbs/digits/tail
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• ectopic ossifications form in 1 of 5 adults
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• distal carpal bones are fused
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• 75% of females exhibit polydactyly
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growth/size/body
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• at E14.5, the body wall is incompletely closed in all embryosat E14.5, the body wall is incompletely closed in all embryos
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Rha mutation
(4 available);
any
Efnb1 mutation
(15 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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Allelic
Composition |
Efnb1tm1Rha/Y
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Genetic
Background |
involves: 129P2/OlaHsd |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Rha mutation
(4 available);
any
Efnb1 mutation
(15 available)
|
|
|
mortality/aging
|
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• about 10% of mice die within 24 hours of birth
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craniofacial
digestive/alimentary system
growth/size/body
Analysis Tools