Phenotypes associated with this allele

• Allele Symbol: Kcnd2^tm1Jmn
• Allele Name: targeted mutation 1, Jeanne M Nerbonne
• Allele ID: MGI:3653698
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnd2^tm1Jmn/Kcnd2^tm1Jmn	FVB.129-Kcnd2^tm1Jmn	MGI:3653875
hm2	Kcnd2^tm1Jmn/Kcnd2^tm1Jmn	involves: 129S1/Sv * 129X1/SvJ	MGI:3653874

Genotype
MGI:3653875

hm1

• Allelic Composition: Kcnd2^tm1Jmn/Kcnd2^tm1Jmn
• Genetic Background: FVB.129-Kcnd2^tm1Jmn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:110968 )

• after formalin injection, mutants exhibit an elevated second phase response compared to wild-type but lack a peak second phase

nervous system

abnormal channel response ( J:111318 )

• ventricular myocytes lack a fast component of recovery to their fast inactivating/recovering transient outward current

• mutant myocytes are not sensitive to heterpodatoxin, as transient outward currents are not reduced compared to the effect in wild-type

Genotype
MGI:3653874

hm2

• Allelic Composition: Kcnd2^tm1Jmn/Kcnd2^tm1Jmn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

behavior/neurological

hyperresponsive to tactile stimuli ( J:110968 )

• mutants show enhanced sensitivity to mechanical stimuli: thresholds to von Frey filament stimuli and noxious pressure on the tail are reduced relative to wild-type

decreased thermal nociceptive threshold ( J:110968 )

• latencies to withdrawal are shorter in the hot plate test compared to wild-type

nervous system

abnormal neuron morphology ( J:110968 )

• laminaI/II dorsal horn neurons in the mutant spinal cord show decreased excitability in slices compared to wild-type

abnormal channel response ( J:110968 )

• amplitude of A-type potassium currents in cultured neurons from mutants are decreased by 56% compared to wild-type

• recovery of A-type currents from inactiviation is slower in neurons from mutants