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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		M6prtm1Hlk
targeted mutation 1, Bernard Hoflack
MGI:3653697
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		M6prtm1Hlk/M6prtm1Hlk involves: 129P2/OlaHsd * C57BL/6J MGI:3653863
cx2
 		Igf2tm1Rob/Igf2tm1Rob
M6prtm1Hlk/M6prtm1Hlk 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820294
cx3
 		Igf2tm1Rob/Igf2+
M6prtm1Hlk/M6prtm1Hlk 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820295
cx4
 		Igf2tm1Rob/Igf2tm1Rob
M6prtm1Hlk/M6pr+ 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820296
cx5
 		Igf2tm1Rob/Igf2+
M6prtm1Hlk/M6pr+ 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820297
cx6
 		Igf2tm1Rob/Igf2tm1Rob
Igf2rtm2Arge/Igf2r+
M6prtm1Hlk/M6prtm1Hlk 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820301
cx7
 		Igf2tm1Rob/Igf2tm1Rob
Igf2rtm1Arge/Igf2r+
M6prtm1Hlk/M6prtm1Hlk 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820302
cx8
 		Igf2tm1Rob/Igf2+
Igf2rtm2Arge/Igf2r+
M6prtm1Hlk/M6prtm1Hlk 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820303
cx9
 		Igf2tm1Rob/Igf2+
Igf2rtm1Arge/Igf2r+
M6prtm1Hlk/M6prtm1Hlk 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820304
cx10
 		Igf2tm1Rob/Igf2tm1Rob
Igf2rtm2Arge/Igf2r+
M6prtm1Hlk/M6pr+ 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820305
cx11
 		Igf2tm1Rob/Igf2tm1Rob
Igf2rtm1Arge/Igf2r+
M6prtm1Hlk/M6pr+ 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820306
cx12
 		Igf2tm1Rob/Igf2+
Igf2rtm2Arge/Igf2r+
M6prtm1Hlk/M6pr+ 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820307
cx13
 		Igf2tm1Rob/Igf2+
Igf2rtm1Arge/Igf2r+
M6prtm1Hlk/M6pr+ 		involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv MGI:3820308


Genotype
MGI:3653863
hm1
Allelic
Composition		 M6prtm1Hlk/M6prtm1Hlk
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased lysosomal enzyme secretion ( J:111016 )
• in embryonic and adult skin fibroblasts intracellular lysosomal emzyme levels are decreased
• embryonic fibroblasts and thymocytes secrete higher levels of phosphorylated ligands of lysosomal enzymes
lysosomal protein accumulation ( J:111016 )
• in embryonic and adult skin fibroblasts dense inclusions are seen in the cytoplasm and large vacuoles often consisting of compact clusters of smaller translucent vesicles are seen

homeostasis/metabolism
abnormal urine homeostasis ( J:111016 )
• about a 5-fold increase in mannose-6-phosphate containing glycoprotein levels
abnormal enzyme/coenzyme activity ( J:111016 )
• about a 2-fold increase in serum beta-galactosidase, beta-glucuronidase, and arylsulfatase activities

skeleton
skeleton phenotype ( J:111016 )
N
• no signs of joint stiffness are detected

renal/urinary system
abnormal urine homeostasis ( J:111016 )
• about a 5-fold increase in mannose-6-phosphate containing glycoprotein levels




Genotype
MGI:3820294
cx2
Allelic
Composition		 Igf2tm1Rob/Igf2tm1Rob
M6prtm1Hlk/M6prtm1Hlk
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:34584 )
• mice are dwarfed




Genotype
MGI:3820295
cx3
Allelic
Composition		 Igf2tm1Rob/Igf2+
M6prtm1Hlk/M6prtm1Hlk
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:34584 )
• when Igf2tm1Rob is inherited paternally, mice are dwarfed




Genotype
MGI:3820296
cx4
Allelic
Composition		 Igf2tm1Rob/Igf2tm1Rob
M6prtm1Hlk/M6pr+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:34584 )
• mice are dwarfed




Genotype
MGI:3820297
cx5
Allelic
Composition		 Igf2tm1Rob/Igf2+
M6prtm1Hlk/M6pr+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:34584 )
• when Igf2tm1Rob is inherited paternally, mice are dwarfed




Genotype
MGI:3820301
cx6
Allelic
Composition		 Igf2tm1Rob/Igf2tm1Rob
Igf2rtm2Arge/Igf2r+
M6prtm1Hlk/M6prtm1Hlk
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation (0 available); any Igf2r mutation (98 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:34584 )
• when Igf2rtm2Arge is inherited maternally, mice die within 4 weeks of birth

behavior/neurological
abnormal gait ( J:34584 )
• when Igf2rtm2Arge is inherited maternally, mice exhibit a waddling gait

growth/size/body
decreased body size ( J:34584 )
• when Igf2rtm2Arge is inherited maternally, mice are dwarfed




Genotype
MGI:3820302
cx7
Allelic
Composition		 Igf2tm1Rob/Igf2tm1Rob
Igf2rtm1Arge/Igf2r+
M6prtm1Hlk/M6prtm1Hlk
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm1Arge mutation (0 available); any Igf2r mutation (98 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:34584 )
• when Igf2rtm1Arge is inherited maternally, mice die within 4 weeks of birth

behavior/neurological
abnormal gait ( J:34584 )
• when Igf2rtm1Arge is inherited maternally, mice exhibit a waddling gait

growth/size/body
decreased body size ( J:34584 )
• when Igf2rtm1Arge is inherited maternally, mice are dwarfed




Genotype
MGI:3820303
cx8
Allelic
Composition		 Igf2tm1Rob/Igf2+
Igf2rtm2Arge/Igf2r+
M6prtm1Hlk/M6prtm1Hlk
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation (0 available); any Igf2r mutation (98 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:34584 )
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body
decreased body size ( J:34584 )
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are dwarfed

behavior/neurological
abnormal gait ( J:34584 )
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice exhibit a waddling gait




Genotype
MGI:3820304
cx9
Allelic
Composition		 Igf2tm1Rob/Igf2+
Igf2rtm1Arge/Igf2r+
M6prtm1Hlk/M6prtm1Hlk
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm1Arge mutation (0 available); any Igf2r mutation (98 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:34584 )
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body
decreased body size ( J:34584 )
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice are dwarfed

behavior/neurological
abnormal gait ( J:34584 )
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice exhibit a waddling gait




Genotype
MGI:3820305
cx10
Allelic
Composition		 Igf2tm1Rob/Igf2tm1Rob
Igf2rtm2Arge/Igf2r+
M6prtm1Hlk/M6pr+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation (0 available); any Igf2r mutation (98 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:34584 )
N
• when Igf2rtm2Arge is inherited maternally, mice are viable

growth/size/body
decreased body size ( J:34584 )
• when Igf2rtm2Arge is inherited maternally, mice are dwarfed

reproductive system
reproductive system phenotype ( J:34584 )
N
• when Igf2rtm2Arge is inherited maternally, mice are fertile




Genotype
MGI:3820306
cx11
Allelic
Composition		 Igf2tm1Rob/Igf2tm1Rob
Igf2rtm1Arge/Igf2r+
M6prtm1Hlk/M6pr+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm1Arge mutation (0 available); any Igf2r mutation (98 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:34584 )
N
• when Igf2rtm1Arge is inherited maternally, mice are viable

growth/size/body
decreased body size ( J:34584 )
• when Igf2rtm1Arge is inherited maternally, mice are dwarfed

reproductive system
reproductive system phenotype ( J:34584 )
N
• when Igf2rtm1Arge is inherited maternally, mice are fertile




Genotype
MGI:3820307
cx12
Allelic
Composition		 Igf2tm1Rob/Igf2+
Igf2rtm2Arge/Igf2r+
M6prtm1Hlk/M6pr+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm2Arge mutation (0 available); any Igf2r mutation (98 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:34584 )
N
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are viable

growth/size/body
decreased body size ( J:34584 )
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are dwarfed

reproductive system
reproductive system phenotype ( J:34584 )
N
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are fertile




Genotype
MGI:3820308
cx13
Allelic
Composition		 Igf2tm1Rob/Igf2+
Igf2rtm1Arge/Igf2r+
M6prtm1Hlk/M6pr+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm1Arge mutation (0 available); any Igf2r mutation (98 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
M6prtm1Hlk mutation (0 available); any M6pr mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:34584 )
N
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice are viable

growth/size/body
decreased body size ( J:34584 )
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice are dwarfed

reproductive system
reproductive system phenotype ( J:34584 )
N
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice are fertile




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory