About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ighdtm1Lam
targeted mutation 1, Marinus C Lamers
MGI:3653691
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ighdtm1Lam/Ighdtm1Lam involves: 129S2/SvPas * C57BL/6 MGI:3653763
ht2
 		Ighdtm1Lam/Ighd+ involves: 129S2/SvPas * C57BL/6 MGI:3653764


Genotype
MGI:3653763
hm1
Allelic
Composition		 Ighdtm1Lam/Ighdtm1Lam
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighdtm1Lam mutation (0 available); any Ighd mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukopoiesis ( J:111020 )
• homozygous mice show a reduction of 50-70% in splenocyte and lymph node cell numbers compared to wild-type
abnormal B cell physiology ( J:111020 )
• mutants show slightly lower responses to thymus dependent antigen such as DNP-ovalbumin
increased IgA level ( J:111020 )
• mutants have 2-fold higher IgA than wild-type
decreased IgG2b level ( J:111020 )
• mice have 4.5-fold lower IgG2b levels than wild-type

hematopoietic system
abnormal leukopoiesis ( J:111020 )
• homozygous mice show a reduction of 50-70% in splenocyte and lymph node cell numbers compared to wild-type
abnormal B cell physiology ( J:111020 )
• mutants show slightly lower responses to thymus dependent antigen such as DNP-ovalbumin
increased IgA level ( J:111020 )
• mutants have 2-fold higher IgA than wild-type
decreased IgG2b level ( J:111020 )
• mice have 4.5-fold lower IgG2b levels than wild-type




Genotype
MGI:3653764
ht2
Allelic
Composition		 Ighdtm1Lam/Ighd+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighdtm1Lam mutation (0 available); any Ighd mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:111020 )
• heterozygotes have ~ 50% fewer B cells of the Iga allotype in the spleen and lymph nodes

immune system
decreased B cell number ( J:111020 )
• heterozygotes have ~ 50% fewer B cells of the Iga allotype in the spleen and lymph nodes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory