Phenotypes associated with this allele

• Allele Symbol: Pten^tm1.1Hwu
• Allele Name: targeted mutation 1.1, Hong Wu
• Allele ID: MGI:3653378
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pten^tm1.1Hwu/Pten^tm1.1Hwu	involves: 129S4/SvJae * BALB/c	MGI:3707138
ht2	Pten^tm1.1Hwu/Pten^+	involves: 129S4/SvJae * BALB/c	MGI:3707122
ht3	Pten^tm1.1Hwu/Pten^+	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:3707123
ht4	Pten^tm1.1Hwu/Pten^+	involves: 129S4/SvJae * C57BL/6NTac	MGI:5008590
cx5	Pten^tm1.1Hwu/Pten^+ Tmprss2^tm1.1(ERG)Sho/Tmprss2^tm1.1(ERG)Sho	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:5578646
cx6	Pten^tm1.1Hwu/Pten^+ Tmprss2^tm2.1(ETV1)Sho/Tmprss2^tm2.1(ETV1)Sho	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:5578648
cx7	Del(16Tmprss2-Erg)1Sho/Del(16Tmprss2-Erg)1Sho Pten^tm1.1Hwu/Pten^+	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:5578651
cx8	Gt(ROSA)26Sor^tm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor^+ Pten^tm1.1Hwu/Pten^+	involves: 129S4/SvJae * C57BL/6NTac	MGI:5008591

Genotype
MGI:3707138

hm1

• Allelic Composition: Pten^tm1.1Hwu/Pten^tm1.1Hwu
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:110567 )

• embryos die between day E9.5 and E10.5

cardiovascular system

abnormal pericardium development ( J:110567 )

• embryos exhibit a bulged pericardial cavity at E9-9.5

nervous system

open neural tube ( J:110567 )

• failure of neural tube closure is observed at E9.9.5

wavy neural tube ( J:110567 )

• E9-9.5 homozygous embryos display a wavy neural tube

embryo

open neural tube ( J:110567 )

• failure of neural tube closure is observed at E9.9.5

wavy neural tube ( J:110567 )

• E9-9.5 homozygous embryos display a wavy neural tube

Genotype
MGI:3707122

ht2

• Allelic Composition: Pten^tm1.1Hwu/Pten⁺
• Genetic Background: involves: 129S4/SvJae * BALB/c

neoplasm

abnormal metastatic potential ( J:110567 )

• most of the tumor seen are benign and isolated, but in three cases malignant transformation was observed; in two mice, local invasion occurred while in one, whole body metastasis occurred

abnormal tumor incidence ( J:110567 )

• onset of tumor formation on the BALB/c background is delayed compared to that reported on other backgrounds; 90% of heterozygotes are tumor-free for their first 6 months, and only 50% have developed tumors by 10 months of age

• Background Sensitivity: 9% of aged 7-14 month old females show endometrial hyperplasia on this background

increased mammary adenocarcinoma incidence ( J:110567 )

• 30% of females develop mammary tumors ranging from 1-10 tumors per animal

increased prostate gland tumor incidence ( J:110567 )

♂ • 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion

increased hemangioma incidence ( J:110567 )

• 45% of female uteri have hemangioma lesions at 7-14 months; these masses consist of aggregates of endothelium-lined blood filled spaces of variable sizes

• in some areas, tissue resembled arterioles or venules, while at edges of large spaces, there are small capillary aggregates; smaller vessels are packed with erythrocytes

• vascular abnormalities are also found in the brain, mammary glands, spinal cord or body walls of some heterozygotes, but at lower frequencies than in the uterus

cardiovascular system

abnormal brain vasculature morphology ( J:110567 )

• similar lesions to those in the uterus are occasionally observed in the brain of some mice at 14 months

• in a male at 14 months, the lesions of the cerebrum and olfactory bulb were aggregates of endothelium-lined, cavernous blood-filled spaces separated by narrow connective-tissue septa; blood in some spaces was thrombosed and calcified

• aggregates of capillary arteriole- and venule-like vessels similar to the ones in the uteri are observed

reproductive system

increased prostate gland tumor incidence ( J:110567 )

♂ • 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion

abnormal uterus morphology ( J:110567 )

♀ • hemangiomas are predominantly in the myometrium, involve the whole uterine wall, and protrude into the uterine lumen

immune system

lymphoid hyperplasia ( J:110567 )

• incidence of lymphoid hyperplasia or neoplasia is 25%

nervous system

abnormal brain vasculature morphology ( J:110567 )

• similar lesions to those in the uterus are occasionally observed in the brain of some mice at 14 months

• in a male at 14 months, the lesions of the cerebrum and olfactory bulb were aggregates of endothelium-lined, cavernous blood-filled spaces separated by narrow connective-tissue septa; blood in some spaces was thrombosed and calcified

• aggregates of capillary arteriole- and venule-like vessels similar to the ones in the uteri are observed

abnormal olfactory bulb morphology ( J:110567 )

• in a male at 14 months, the left olfactory bulb and frontal lobes of the cerebrum seem to be replaced by masses of hemorrhagic-appearing tissue; the mouse seemed ataxic, with enlargement of the forehead

integument

increased mammary adenocarcinoma incidence ( J:110567 )

• 30% of females develop mammary tumors ranging from 1-10 tumors per animal

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:110567 )

• 30% of females develop mammary tumors ranging from 1-10 tumors per animal

increased prostate gland tumor incidence ( J:110567 )

♂ • 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion

Genotype
MGI:3707123

ht3

• Allelic Composition: Pten^tm1.1Hwu/Pten⁺
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

neoplasm

abnormal tumor incidence ( J:110567 )

• Background Sensitivity: 25% of aged 7-14 month old F2 females show endometrial hyperplasia compared to 9% on 129/BALB/c background

Genotype
MGI:5008590

ht4

• Allelic Composition: Pten^tm1.1Hwu/Pten⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

neoplasm

increased thyroid adenoma incidence ( J:170965 )

increased lymphoma incidence ( J:170965 )

• at 6 to 7 months of age

endocrine/exocrine glands

increased thyroid adenoma incidence ( J:170965 )

Genotype
MGI:5578646

cx5

• Allelic Composition: Pten^tm1.1Hwu/Pten⁺; Tmprss2^{tm1.1(ERG)Sho}/Tmprss2^{tm1.1(ERG)Sho}
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

Genotype
MGI:5578648

cx6

• Allelic Composition: Pten^tm1.1Hwu/Pten⁺; Tmprss2^{tm2.1(ETV1)Sho}/Tmprss2^{tm2.1(ETV1)Sho}
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

Genotype
MGI:5578651

cx7

• Allelic Composition: Del(16Tmprss2-Erg)1Sho/Del(16Tmprss2-Erg)1Sho; Pten^tm1.1Hwu/Pten⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

Genotype
MGI:5008591

cx8

• Allelic Composition: Gt(ROSA)26Sor^{tm1(H1/tetO-RNAi:Pdpk1)Mrl}/Gt(ROSA)26Sor⁺; Pten^tm1.1Hwu/Pten⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

neoplasm

increased thyroid adenoma incidence ( J:170965 )

• in doxycycline-treated mice

increased lymphoma incidence ( J:170965 )

• at 6 to 7 months of age in doxycycline-treated mice

endocrine/exocrine glands

increased thyroid adenoma incidence ( J:170965 )

• in doxycycline-treated mice