neoplasm
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• most of the tumor seen are benign and isolated, but in three cases malignant transformation was observed; in two mice, local invasion occurred while in one, whole body metastasis occurred
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• onset of tumor formation on the BALB/c background is delayed compared to that reported on other backgrounds; 90% of heterozygotes are tumor-free for their first 6 months, and only 50% have developed tumors by 10 months of age
• Background Sensitivity: 9% of aged 7-14 month old females show endometrial hyperplasia on this background
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• 30% of females develop mammary tumors ranging from 1-10 tumors per animal
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• 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion
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• 45% of female uteri have hemangioma lesions at 7-14 months; these masses consist of aggregates of endothelium-lined blood filled spaces of variable sizes
• in some areas, tissue resembled arterioles or venules, while at edges of large spaces, there are small capillary aggregates; smaller vessels are packed with erythrocytes
• vascular abnormalities are also found in the brain, mammary glands, spinal cord or body walls of some heterozygotes, but at lower frequencies than in the uterus
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cardiovascular system
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• similar lesions to those in the uterus are occasionally observed in the brain of some mice at 14 months
• in a male at 14 months, the lesions of the cerebrum and olfactory bulb were aggregates of endothelium-lined, cavernous blood-filled spaces separated by narrow connective-tissue septa; blood in some spaces was thrombosed and calcified
• aggregates of capillary arteriole- and venule-like vessels similar to the ones in the uteri are observed
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reproductive system
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• 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion
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• hemangiomas are predominantly in the myometrium, involve the whole uterine wall, and protrude into the uterine lumen
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immune system
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• incidence of lymphoid hyperplasia or neoplasia is 25%
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nervous system
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• similar lesions to those in the uterus are occasionally observed in the brain of some mice at 14 months
• in a male at 14 months, the lesions of the cerebrum and olfactory bulb were aggregates of endothelium-lined, cavernous blood-filled spaces separated by narrow connective-tissue septa; blood in some spaces was thrombosed and calcified
• aggregates of capillary arteriole- and venule-like vessels similar to the ones in the uteri are observed
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• in a male at 14 months, the left olfactory bulb and frontal lobes of the cerebrum seem to be replaced by masses of hemorrhagic-appearing tissue; the mouse seemed ataxic, with enlargement of the forehead
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integument
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• 30% of females develop mammary tumors ranging from 1-10 tumors per animal
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endocrine/exocrine glands
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• 30% of females develop mammary tumors ranging from 1-10 tumors per animal
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• 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion
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Analysis Tools