Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rp1tm1Eap mutation
(0 available);
any
Rp1 mutation
(121 available)
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vision/eye
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• photoreceptor axonemes are significantly shorter than in wild-type or Rp1htm1Jnz mice
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• accumulation of short stacks of enlarged disoriented discs in place of organized outer segments
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nervous system
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• photoreceptor axonemes are significantly shorter than in wild-type or Rp1htm1Jnz mice
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• accumulation of short stacks of enlarged disoriented discs in place of organized outer segments
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Allelic
Composition |
Rp1tm1Eap/Rp1tm1Eap
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Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rp1tm1Eap mutation
(0 available);
any
Rp1 mutation
(121 available)
|
|
|
vision/eye
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|
• at 10 days of age, new evaginations at the base of the outer segments lose their perpendicular orientation quickly forming discs parallel not perpendicular to the long axis of the axoneme or closely aligned along the axoneme as in controls
• at 14 days of age, homozygotes lack organized arrangement of stacked discs in the photoreceptor outer segments; stacks of discs are obliquely or aligned to along the long axis of the photoreceptor cells rather than perpendicular
• discs are 2-3 times larger than in controls
• mice exhibit a progressive deterioration of photoreceptor cells
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• the ONL of the retina is 2-3 cell layers thinner than wild-type
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• at 10 months of age retinal degeneration is almost total with only 2 rows of photoreceptor nuclei remaining compared to heterozygotes and wild-type; rows contain both rods and cones that have abnormal outer segments
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• cone b-waves are reduced significantly at 4-8 months of age
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• saturating amplitude of the rod a-wave is reduced by 58% in 4-5 week old homozygotes and is practically absent at 4-8 months of age
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nervous system
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• at 10 days of age, new evaginations at the base of the outer segments lose their perpendicular orientation quickly forming discs parallel not perpendicular to the long axis of the axoneme or closely aligned along the axoneme as in controls
• at 14 days of age, homozygotes lack organized arrangement of stacked discs in the photoreceptor outer segments; stacks of discs are obliquely or aligned to along the long axis of the photoreceptor cells rather than perpendicular
• discs are 2-3 times larger than in controls
• mice exhibit a progressive deterioration of photoreceptor cells
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Allelic
Composition |
Rp1tm1Eap/Rp1+
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|
Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rp1tm1Eap mutation
(0 available);
any
Rp1 mutation
(121 available)
|
|
|
vision/eye
|
|
• cone b-waves are reduced significantly at 4-8 months of age
|
|
|
• saturating amplitude of the rod a-wave is reduced by 58% in 4-5 week old homozygotes and is practically absent at 4-8 months of age
|
Allelic
Composition |
Rp1tm1Jnz/Rp1tm1Eap
|
|
Genetic
Background |
involves: 129S6/SvEvTac * 129S7/SvEvBrd |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rp1tm1Eap mutation
(0 available);
any
Rp1 mutation
(121 available)
Rp1tm1Jnz mutation
(0 available);
any
Rp1 mutation
(121 available)
|
|
|
vision/eye
|
|
• accumulation of short stacks of enlarged disoriented discs in place of organized outer segments
|
nervous system
|
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• accumulation of short stacks of enlarged disoriented discs in place of organized outer segments
|
Analysis Tools