About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gba1tm1Bst
targeted mutation 1, Paul Bornstein
MGI:3652590
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Gba1tm1Bst/Gba1tm1Bst
Gba/Mtx1tm1Bst/Gba/Mtx1tm1Bst 		involves: 129S4/SvJae MGI:3652807
cx2
 		Gba1tm1Bst/Gba1tm1Nsb
Gba/Mtx1tm1Bst/Mtx1+ 		involves: 129S/SvEv * 129S4/SvJae MGI:3652806


Genotype
MGI:3652807
cx1
Allelic
Composition		 Gba1tm1Bst/Gba1tm1Bst
Gba/Mtx1tm1Bst/Gba/Mtx1tm1Bst
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Bst mutation (0 available); any Gba1 mutation (43 available)
Gba/Mtx1tm1Bst mutation (0 available); any Mtx1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:25197 )
• examination of pregnant mice at 9 days post conception revealed multiple sites of resorption among the developing embryos; homozygous embryos die between day 4 and 9




Genotype
MGI:3652806
cx2
Allelic
Composition		 Gba1tm1Bst/Gba1tm1Nsb
Gba/Mtx1tm1Bst/Mtx1+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Bst mutation (0 available); any Gba1 mutation (43 available)
Gba1tm1Nsb mutation (2 available); any Gba1 mutation (43 available)
Gba/Mtx1tm1Bst mutation (0 available); any Mtx1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:25197 )
• animals die within 24 hours of birth

homeostasis/metabolism
abnormal enzyme/coenzyme level ( J:25197 )
• mutants have about 5% of control glucocerebrosidase activity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory