Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcan1tm1Jmol mutation
(1 available);
any
Rcan1 mutation
(24 available)
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growth/size/body
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• in response to pressure overload stimulus mutants show less increase in heart weight normalized to tibia length sompared to wild-type
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• homozygotes exhibit an ~10% decrease in body weight with age
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cardiovascular system
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• myocyte area (hypertrophy) is less than that observed in wild-type in response to pressure overload
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• in response to pressure overload stimulus mutants show less increase in heart weight normalized to tibia length sompared to wild-type
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• hypertrophy and increase in heart weight is reduced in response to pressure overload compared to wild-type
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• myocardial damage is increased in mice after ischemia-reperfusion injury
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reproductive system
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• mice exhibit reduced fertility with age
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homeostasis/metabolism
muscle
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• myocyte area (hypertrophy) is less than that observed in wild-type in response to pressure overload
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behavior/neurological
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• mice show subtle but significant impairment in working memory assessed by novel and familiar object recognition
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• mice show a significant increase in cumulative activity during light and dark conditions
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immune system
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• in response to stimulation, total splenocytes show reduced proliferation
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• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
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• in response to stimulation, total splenocytes show reduced proliferation and Il2 production compared to wild-type
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cardiovascular system
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• mice do not display cardiac hypertrophy in response to 2 weeks of infusion of phenylephrine plus angiotensin II or 3 weeks of forced exercise unlike wild-type mice
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• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated
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• myocardial damage is increased in mice after ischemia-reperfusion injury
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hematopoietic system
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• in response to stimulation, total splenocytes show reduced proliferation
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• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
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homeostasis/metabolism
cellular
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• in response to stimulation, total splenocytes show reduced proliferation
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muscle
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• mice do not display cardiac hypertrophy in response to 2 weeks of infusion of phenylephrine plus angiotensin II or 3 weeks of forced exercise unlike wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcan1tm1Jmol mutation
(1 available);
any
Rcan1 mutation
(24 available)
Tg(Myh6-Ppp3ca)37Eno mutation
(1 available)
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cardiovascular system
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• Dscr1-deficiency induces a greater increase in cardiac hypertrophy in combination with Tg(Myh6-Ppp3ca)37Eno expression than in wild-type or Dscr1l1-deficiency with transgene expression
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growth/size/body
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• Dscr1-deficiency induces a greater increase in cardiac hypertrophy in combination with Tg(Myh6-Ppp3ca)37Eno expression than in wild-type or Dscr1l1-deficiency with transgene expression
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behavior/neurological
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• mice show a significant increase in cumulative activity during light and dark conditions, even greater than that shown in Dscr1/Dscr1l1 knockouts
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immune system
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• in response to stimulation, total splenocytes show reduced proliferation
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• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
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• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
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• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
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• in response to stimulation, total splenocytes show increased Il2 production compared to wild-type
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hematopoietic system
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• in response to stimulation, total splenocytes show reduced proliferation
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• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
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• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
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• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
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cardiovascular system
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• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated
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homeostasis/metabolism
cellular
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• in response to stimulation, total splenocytes show reduced proliferation
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