All Phenotypes Wnt7b<tm1Eem> MGI Mouse

neonatal lethality, complete penetrance ( J:79395 )

• die within 10 minutes of birth

lung hemorrhage ( J:79395 )

• present in neonates, particularly around the large blood vessels; however no signs of hemorrhage are seen any where else in the body

• rupture of the vascular smooth muscle wall and herniation of the endothelial lining is seen in several vessel that show hemorrhage

abnormal lung morphology ( J:79395 )

abnormal lung vasculature morphology ( J:79395 )

• large vessels appear dilated, the smooth muscle layer appears hypertrophic, and at E18.5 branching of the smaller vessels is reduced

• some large vessels have less smooth muscle and in neonates increased TUNEL staining is seen in vascular smooth muscle cells but not in bronchial smooth muscle

abnormal mesenchymal cell proliferation involved in lung development ( J:79395 )

• at E12.5 proliferation of the distal mesenchyme is reduced by about 2/3 compared to wild-type mice, but by E14.5 a difference in proliferation is no longer detected

thin lung-associated mesenchyme ( J:79395 )

• prominent thinning of the distal mesenchyme at E12.5

• distal mesenchyme is sometimes only one or two cell layers thick

decreased type I pneumocyte number ( J:79395 )

• at E18.5 almost no alveolar epithelial type 1 cells are detected although type 2 cells and surfactant are present

pulmonary hypoplasia ( J:79395 )

• seen at E12.5 with prominent thinning of the distal mesenchyme

respiratory failure ( J:79395 )

• gasp for breath and do not show evidence of air in the distal airways