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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pkd2lrm4
left-right mutant 4
MGI:3640799
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pkd2lrm4/Pkd2lrm4 C3.CAnN-Pkd2lrm4 MGI:4948355
hm2
 		Pkd2lrm4/Pkd2lrm4 involves: BALB/cAnN * C3H/HeH MGI:3834138
cx3
 		Pkd1l1rks/Pkd1l1+
Pkd2lrm4/Pkd2+ 		C3.Cg-Pkd2lrm4 Pkd1l1rks MGI:4948354


Genotype
MGI:4948355
hm1
Allelic
Composition		 Pkd2lrm4/Pkd2lrm4
Genetic
Background		 C3.CAnN-Pkd2lrm4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2lrm4 mutation (0 available); any Pkd2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:170490 )
• embryos fail to survive significantly beyond E14.5

embryo
embryo phenotype ( J:170490 )
N
• embryonic node cilia motion appears normal
abnormal direction of embryo turning ( J:170490 )
• at E9.5 embryos display normal or inverted turning
abnormal left-right axis patterning ( J:170490 )
• expression analysis detects defect in left-right asymmetry of the lateral plate mesoderm

homeostasis/metabolism
edema ( J:170490 )
• in 31 of 33 embryos

growth/size/body
right-sided stomach ( J:170490 )
• in some embryos
right pulmonary isomerism ( J:170490 )
• in 37 of 38 embryos

cardiovascular system
dextrocardia ( J:170490 )
• in some embryos

digestive/alimentary system
right-sided stomach ( J:170490 )
• in some embryos

respiratory system
right pulmonary isomerism ( J:170490 )
• in 37 of 38 embryos




Genotype
MGI:3834138
hm2
Allelic
Composition		 Pkd2lrm4/Pkd2lrm4
Genetic
Background		 involves: BALB/cAnN * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2lrm4 mutation (0 available); any Pkd2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
left pulmonary isomerism ( J:145068 )
• in 4% of mice
right pulmonary isomerism ( J:145068 )
• in 71% of mice
situs inversus ( J:145068 )
• 7% of mice exhibit inverted lungs, and 11% of mice exhibit partial inversion

cardiovascular system
dextrocardia ( J:145068 )
• in 50% of mice
mesocardia ( J:145068 )
• in 4% of mice

digestive/alimentary system
abnormal stomach position or orientation ( J:145068 )
• the stomach is right-sided in 50% of mice and centrally located in 4% of mice

homeostasis/metabolism
edema ( J:145068 )
• 64% of mice exhibit external edema

respiratory system
left pulmonary isomerism ( J:145068 )
• in 4% of mice
right pulmonary isomerism ( J:145068 )
• in 71% of mice




Genotype
MGI:4948354
cx3
Allelic
Composition		 Pkd1l1rks/Pkd1l1+
Pkd2lrm4/Pkd2+
Genetic
Background		 C3.Cg-Pkd2lrm4 Pkd1l1rks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1l1rks mutation (0 available); any Pkd1l1 mutation (155 available)
Pkd2lrm4 mutation (0 available); any Pkd2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:170490 )
• no abnormal kidney, cardiac or situs pathology is detected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory