Analysis Tools
muscle
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• hypertrophy is most likely a consequence of severe lung alterations, eventually leading to a cor pulmonale
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• hypertrophy is most likely a consequence of severe lung alterations, eventually leading to a cor pulmonale
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mortality/aging
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• some die spontaneously during the early postnatal period
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growth/size/body
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• hypertrophy is most likely a consequence of severe lung alterations, eventually leading to a cor pulmonale
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• hypertrophy is most likely a consequence of severe lung alterations, eventually leading to a cor pulmonale
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• relative weight of the heart is increased
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• relative weight of ovaries is increased
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• absolute and relative carcass weight is reduced
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• body weight at 9 weeks of age is reduced
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• reduction in nose-rump length
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• absolute and relative weight of lung is increased
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• relative weight of the liver is increased
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• absolute and relative weight of spleen is increased
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cardiovascular system
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• thickening of the atrioventricular valves, particularly the mitral valve
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• thickening of the mitral valve
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• hearts are round shaped
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• hypertrophy is most likely a consequence of severe lung alterations, eventually leading to a cor pulmonale
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• hypertrophy is most likely a consequence of severe lung alterations, eventually leading to a cor pulmonale
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• relative weight of the heart is increased
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• progressive development of alveolar hemorrhage, with small hemorrhagic foci first seen at 2-3 days of age
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respiratory system
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• progressive development of alveolar hemorrhage, with small hemorrhagic foci first seen at 2-3 days of age
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• exhibit nodular pulmonary remodeling, consisting of multiple foci composed of fibroblasts, collagen fibers, large macrophages, and some proteinaceous deposits
• starting at 2-3 days of age, exhibit progressive development of pulmonary lesions, showing macrophages undergoing erythrophagocytosis and granulocytic inflammation
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• absolute and relative weight of lung is increased
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• distal airspaces are almost completely filled with macrophages and show accumulations of eosinophilic and neutrophilic granulocytes
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• distal air spaces are severely enlarged with little septation
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• commonly observe respiratory distress in adults, characterized by rapid and short breathing movements
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vision/eye
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• absolute and relative weight of eyes is increased
• mutants do not display macroscopically visible eye alterations, however histological examination shows comparable alterations to those seen in Line 2, mainly affecting the lens and retina
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endocrine/exocrine glands
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• pancreas weight is disproportionately decreased to body weight
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• relative weight of ovaries is increased
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hematopoietic system
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• absolute and relative weight of spleen is increased
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homeostasis/metabolism
immune system
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• absolute and relative weight of spleen is increased
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liver/biliary system
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• relative weight of the liver is increased
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reproductive system
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• relative weight of ovaries is increased
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