Phenotypes associated with this allele

• Allele Symbol: Cyp4a10^tm1Jhc
• Allele Name: targeted mutation 1, Jorge H Capdevila
• Allele ID: MGI:3640474
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp4a10^tm1Jhc/Cyp4a10^tm1Jhc	involves: 129S6/SvEvTac	MGI:3640502

Genotype
MGI:3640502

hm1

• Allelic Composition: Cyp4a10^tm1Jhc/Cyp4a10^tm1Jhc
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hypertension ( J:110364 )

• males and females are equally hypertensive

• treatment with amiloride reversibly reduces blood pressure to normal levels even when mice are given 2% salt water

salt-sensitive hypertension ( J:110364 )

• salt-sensitive, mice on a low salt (0.05% w/w) become normotensive

increased systemic arterial systolic blood pressure ( J:110364 )

renal/urinary system

decreased urine potassium level ( J:110364 )

abnormal renal sodium ion transport ( J:110364 )

• increased epithelial sodium channel basal activity

abnormal renal sodium reabsorption ( J:110364 )

• increased sodium reabsorption

oliguria ( J:110364 )

• increases with increased salt in the diet but is always less than in wild-type mice

homeostasis/metabolism

decreased urine potassium level ( J:110364 )

abnormal renal sodium reabsorption ( J:110364 )

• increased sodium reabsorption

growth/size/body

abnormal body water content ( J:110364 )

• increase in free fluid volume compared to wild-type mice when on a normal salt diet