Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-APPSwInd)885Dbo
• Allele Name: transgene insertion 885, David R Borchelt
• Allele ID: MGI:3639702
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-APPSwInd)885Dbo/0 Tg(tetO-LRRK2*G2019S)E3Cai/0	involves: C3H/HeJ * C57BL/6	MGI:4421004
cx2	Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-APPSwInd)885Dbo/0	involves: C3H/HeJ * C57BL/6 * CBA	MGI:3696400

Genotype
MGI:4421004

cx1

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-APPSwInd)885Dbo/0; Tg(tetO-LRRK2*G2019S)E3Cai/0
• Genetic Background: involves: C3H/HeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

neurodegeneration ( J:156512 )

• no acceleration of degeneration is observed compared to Tg(Camk2a-tTA)1Mmay/Tg(tetO-LRRK2*G2019S)E3Cai mice (G2019S)

Genotype
MGI:3696400

cx2

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-APPSwInd)885Dbo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6 * CBA

nervous system

amyloid beta deposits ( J:185792 )

abnormal dentate gyrus morphology ( J:185792 )

• mice exhibit a progressive neuronal atrophy that is most pronounced in the granule cell layer of hippocampal dentate gyrus

hippocampal neuron degeneration ( J:185792 )

• mice exhibit a progressive neuronal atrophy that is most pronounced in the granule cell layer of hippocampal dentate gyrus

• however, when mice are reared on doxycycline, cell loss is not observed

abnormal nervous system physiology ( J:109829 )

• mice produce transgenic APP protein at 10- to 30-fold over endogenous App levels

• expression of APPSw/Ind is higher relative to other three double transgenic lines, and suprression requires more doxycycline than the other three lines

homeostasis/metabolism

amyloid beta deposits ( J:185792 )