Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice
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growth/size/body
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• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• survive to a mean age of 15 weeks; most die after showing signs of heart failure
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cardiovascular system
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• myocyte hypertrophy; the long axis is increased 1.3-fold, the short axis is increased 1.2-fold, the cell area is increased 1.5-fold, and the cell volume is increased 1.9-fold
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• the heart weight/body weight ratio is increased 2.2-fold at 2 and 14 weeks of age
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• significant increase in wall thickness of both the anterior and posterior left ventricular walls at 2 and 14 weeks of age
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• at 14 weeks of age, but not at 2 weeks, the left ventricular (LV) systolic diameter is increased, the LV diastolic diameter is minimally increased, and fractional shortening is decreased to 37%
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muscle
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• myocyte hypertrophy; the long axis is increased 1.3-fold, the short axis is increased 1.2-fold, the cell area is increased 1.5-fold, and the cell volume is increased 1.9-fold
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• at 14 weeks of age, but not at 2 weeks, the left ventricular (LV) systolic diameter is increased, the LV diastolic diameter is minimally increased, and fractional shortening is decreased to 37%
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growth/size/body
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• the heart weight/body weight ratio is increased 2.2-fold at 2 and 14 weeks of age
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cellular
Analysis Tools