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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd8atm1.1Kio
targeted mutation 1.1, Dimitris Kioussis
MGI:3630292
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd8atm1.1Kio/Cd8atm1.1Kio involves: 129S4/SvJae * C57BL/10 * CBA/Ca MGI:3713658


Genotype
MGI:3713658
hm1
Allelic
Composition		 Cd8atm1.1Kio/Cd8atm1.1Kio
Genetic
Background		 involves: 129S4/SvJae * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1.1Kio mutation (0 available); any Cd8a mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive T cell differentiation ( J:76799 )
• thymocytes fail to mature past the CD4+ gate

immune system
abnormal CD4-positive T cell differentiation ( J:76799 )
• thymocytes fail to mature past the CD4+ gate




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory