Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-IGF1R)7Jmcm
• Allele Name: transgene insertion 7, Julie R McMullen
• Allele ID: MGI:3630255
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-IGF1R)7Jmcm/0 Tg(Myh6-Pik3ca)1Siz/0	involves: FVB/N	MGI:3630293
cx2	Tg(Myh6-IGF1R)7Jmcm/0 Tg(Myh6-Pik3r1/PIK3CA)BSiz/0	involves: FVB/N	MGI:3630294
tg3	Tg(Myh6-IGF1R)7Jmcm/0	involves: FVB/N	MGI:3630289

Genotype
MGI:3630293

cx1

• Allelic Composition: Tg(Myh6-IGF1R)7Jmcm/0; Tg(Myh6-Pik3ca)1Siz/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

small heart ( J:87944 )

• the heart weight/body weight ratio is significantly lower than in single Tg(Myh6-IGF1R)7Siz mice and not different from single Tg(Myh6-Pik3ca)1Siz mice

decreased heart weight ( J:87944 )

Genotype
MGI:3630294

cx2

• Allelic Composition: Tg(Myh6-IGF1R)7Jmcm/0; Tg(Myh6-Pik3r1/PIK3CA)BSiz/0
• Genetic Background: involves: FVB/N

cardiovascular system

enlarged heart ( J:87944 )

• exhibit a significant increase in heart size, with an increase in the heart weight/body weight ratio

growth/size/body

enlarged heart ( J:87944 )

• exhibit a significant increase in heart size, with an increase in the heart weight/body weight ratio

Genotype
MGI:3630289

tg3

• Allelic Composition: Tg(Myh6-IGF1R)7Jmcm/0
• Genetic Background: involves: FVB/N

cardiovascular system

increased myocardial fiber size ( J:87944 )

• the short axis and cell area of myocytes are significantly greater and the cell volume is about 46% greater than in wild-type

increased heart weight ( J:87944 )

cardiac hypertrophy ( J:87944 )

• increase in heart size due to an increase in myocyte size, without any evidence of necrosis, fibrosis or myocyte disarray

• the heart weight/body weight and heart weight/tibial length ratios at 3 months of age are increased by about 38 and 34%, respectively

abnormal cardiovascular system physiology ( J:87944 )

• exhibit a greater augmentation of the hypertrophic response to a physiological stimulus (chronic swimming) than to a pathological stimulus (aortic banding)

• hearts of aortic banded mutants have significantly less interstitial fibrosis that aortic banded controls

increased ventricle muscle contractility ( J:87944 )

• fractional shortening is significantly greater (16%) and is maintained at 12-16 months of age

increased left ventricle systolic pressure ( J:87944 )

• left ventricular systolic function, as assessed by fractional shortening, is 16% greater, indicating enhanced systolic function

muscle

increased myocardial fiber size ( J:87944 )

• the short axis and cell area of myocytes are significantly greater and the cell volume is about 46% greater than in wild-type

increased ventricle muscle contractility ( J:87944 )

• fractional shortening is significantly greater (16%) and is maintained at 12-16 months of age

growth/size/body

increased heart weight ( J:87944 )

cardiac hypertrophy ( J:87944 )

• increase in heart size due to an increase in myocyte size, without any evidence of necrosis, fibrosis or myocyte disarray

• the heart weight/body weight and heart weight/tibial length ratios at 3 months of age are increased by about 38 and 34%, respectively