Analysis Tools
skeleton
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• in the femur bone volume in the primary spongiosa is reduced but the secondary spongiosa is unaffected
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• at 8 weeks of age, a decrease in trabecular bone volume is seen mainly at the metaphysis of the tibia; however, cortical bone volume at the diaphysis is similar to wild-type littermates
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• in the femur, the width of the calcified layer and number of calcified chondrocytes are reduced; however, the hypertrophic chondrocyte zone appears normal
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• at 8 weeks of age, a decrease in trabecular bone volume is seen mainly at the metaphysis of the femur and tibia
• femur and tibia bone volume in the cortical bone at the diaphysis is similar to wild-type littermates
• trabecular bone in the vertebral bodies is similar to wild-type
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• during surgically induced osteoarthritis in the knee, cartilage destruction is similar but formation of osteophytes is decreased
• age related ectopic ossification of the patellar ligament and Achilles tendon is decreased
• during fracture healing at the midshaft of the tibia calcification is impaired especially in the middle of the fracture; however formation of the cartilaginous callus is similar to wild-type and bone union is eventually achieved indicating impaired endrochondral ossification but normal intramembranous ossification and osteoblastic bone formation
• in culture, chondrocyte proliferation is similar to wild-type but calcification is suppressed
• calcification of auricular cartilage on a high inorganic phosphate diet is reduced compared to wild-type
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homeostasis/metabolism
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• serum insulin levels are similar to wild-type
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limbs/digits/tail
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• in the femur bone volume in the primary spongiosa is reduced but the secondary spongiosa is unaffected
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• at 8 weeks of age, a decrease in trabecular bone volume is seen mainly at the metaphysis of the tibia; however, cortical bone volume at the diaphysis is similar to wild-type littermates
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