All Phenotypes Ncstn<tm1Rroz> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:108976 )

• homozygotes die before E12.5; numerous resorption sites are detected at E12.5

• expected numbers of homozygotes are found at E10.5

abnormal vitelline vasculature morphology ( J:108976 )

• vascularization of yolk sac is abnormal

abnormal first pharyngeal arch morphology ( J:108976 )

• at E10.5, there is increased apoptosis within the first branchial arch

abnormal rostral-caudal body axis extension ( J:108976 )

• caudal region of homozygotes is severely malformed at E10.5

decreased embryo size ( J:108976 )

• at E9.5 and E10.5, homozygous embryos are significantly smaller than wild-type or heterozygous littermates, but there are no gross signs of mortality; at E10.5, homozygotes are ~25% the size of littermates

abnormal neural crest morphology ( J:108976 )

• at E10.5, there is increased apoptosis within neural crest tissue

kinked neural tube ( J:108976 )

• neural tube genesis is abnormal with anomalous flexures in the neural tube

abnormal somite development ( J:108976 )

• at E10.5, defects in somite segmentation are apparent

increased apoptosis ( J:108976 )

• at E10.5, there is increased apoptosis within neuroepithelium, neural crest tissue, optic vesicle and first branchial arch, structures which display developmental defects in homozygotes

increased embryonic neuroepithelium apoptosis ( J:108976 )

• at E10.5, there is increased apoptosis within the neuroepithelium