Phenotypes associated with this allele

• Allele Symbol: Dph3^tm1Lepp
• Allele Name: targeted mutation 1, Stephen H Leppla
• Allele ID: MGI:3629060
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dph3^tm1Lepp/Dph3^tm1Lepp	involves: 129S1/Sv * C57BL/6	MGI:3629230

Genotype
MGI:3629230

hm1

• Allelic Composition: Dph3^tm1Lepp/Dph3^tm1Lepp
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:109066 )

• all are reabsorbed by E11.5 - E12.5

growth/size/body

embryonic growth retardation ( J:109066 )

• visible at E8.5

• at E10.5 embryos appear to be delayed by at least 2 days compared to wild-type

decreased embryo size ( J:109066 )

• at E8.5

embryo

delayed embryo turning ( J:109066 )

• do not turn until E10.5

embryonic growth retardation ( J:109066 )

• visible at E8.5

• at E10.5 embryos appear to be delayed by at least 2 days compared to wild-type

decreased embryo size ( J:109066 )

• at E8.5

abnormal neural tube morphology ( J:109066 )

• at E10.5 increased necrosis and apoptosis is associated with a smaller, thinner neural tube

neural tube degeneration ( J:109066 )

• at E10.5

abnormal placenta labyrinth morphology ( J:109066 )

• at E9.5 the labyrinth is thinner and lacks immature nucleated erythrocytes

• at E10.5, these defects are more severe

abnormal placental labyrinth vasculature morphology ( J:109066 )

• at E9.5 the labyrinth lacks embryonic blood vessels

• at E10.5, this defect is more severe

small placenta ( J:109066 )

• at E10.5 placental size is significantly reduced

failure of chorioallantoic fusion ( J:109066 )

• not fused at E8.5

nervous system

increased neural tube apoptosis ( J:109066 )

• at E10.5

abnormal neural tube morphology ( J:109066 )

• at E10.5 increased necrosis and apoptosis is associated with a smaller, thinner neural tube

neural tube degeneration ( J:109066 )

• at E10.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:109066 )

• at E9.5 the labyrinth lacks embryonic blood vessels

• at E10.5, this defect is more severe

cellular

increased neural tube apoptosis ( J:109066 )

• at E10.5