Phenotypes associated with this allele

• Allele Symbol: Dfb
• Allele Name: deaf ballerina
• Allele ID: MGI:3628786
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dfb/Dfb^+	BALB/cByJ-Dfb/J	MGI:3639861
ht2	Dfb/Dfb^+	involves: BALB/cByJ * BALB/cJ * C57BL/6J	MGI:3639862

Genotype
MGI:3639861

ht1

• Allelic Composition: Dfb/Dfb⁺
• Genetic Background: BALB/cByJ-Dfb/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Absent corpus callosum in Dfb/Dfb⁺ mice

behavior/neurological

head tossing ( J:110189 )

bidirectional circling ( J:110189 )

nervous system

absent corpus callosum ( J:110189 )

• Background Sensitivity: complete penetrance of acallosal phenotype on BALB background but incomplete penetrance on a mixed BALB and C57BL/6J background

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:110189 )

• thresholds greater than 50 dB above normal

deafness ( J:110189 )

• Background Sensitivity: deafness is more severe on BALB background than on a mixed BALB and C57BL/6J background

reproductive system

small testis ( J:110189 )

♂

female infertility ( J:110189 )

♀

endocrine/exocrine glands

small testis ( J:110189 )

♂

growth/size/body

decreased body size ( J:110189 )

• heterozygotes of both genders are slightly smaller and have less fat than wildtype controls

adipose tissue

decreased percent body fat/body weight ( J:110189 )

Genotype
MGI:3639862

ht2

• Allelic Composition: Dfb/Dfb⁺
• Genetic Background: involves: BALB/cByJ * BALB/cJ * C57BL/6J

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:110189 )

• Background Sensitivity: decreased penetrance on mixed BALB and C57BL/6J background

• severe hearing loss with thresholds 20-40 dB above those of non-circling mice

nervous system

absent corpus callosum ( J:110189 )

• Background Sensitivity: drops to approximately 85% penetrance of acallosal phenotype in mixed BALB and C57BL/6J background