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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2i7
i7 variant
MGI:3628766
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2i7/H2i7 NOD.Cg-H2i7 MGI:3628775
ht2
 		H2i7/H2g7 (NOD x NOD.Cg-H2i7)F1 MGI:3628793
ht3
 		H2i7/H2g7 NOD.Cg-H2i7 MGI:3628791


Genotype
MGI:3628775
hm1
Allelic
Composition		 H2i7/H2i7
Genetic
Background		 NOD.Cg-H2i7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2i7 mutation (1 available); any H2 mutation (280 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
periinsulitis ( J:14178 )
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 9 months of age; mice between 10 and 12 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:14178 )
• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

immune system
periinsulitis ( J:14178 )
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 9 months of age; mice between 10 and 12 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates
decreased susceptibility to autoimmune diabetes ( J:14178 )
• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation




Genotype
MGI:3628793
ht2
Allelic
Composition		 H2i7/H2g7
Genetic
Background		 (NOD x NOD.Cg-H2i7)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (24 available); any H2 mutation (280 available)
H2i7 mutation (1 available); any H2 mutation (280 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:14178 )
• no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis

immune system
insulitis ( J:14178 )
• no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis




Genotype
MGI:3628791
ht3
Allelic
Composition		 H2i7/H2g7
Genetic
Background		 NOD.Cg-H2i7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (24 available); any H2 mutation (280 available)
H2i7 mutation (1 available); any H2 mutation (280 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:14178 )
• no females develop diabetes spontaneously over 5-7 months




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory