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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2i5
i5 variant
MGI:3628763
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2i5/H2i5 NOD.Cg-H2i5 MGI:3628774
ht2
 		H2i5/H2g7 NOD.Cg-H2i5 MGI:3628789


Genotype
MGI:3628774
hm1
Allelic
Composition		 H2i5/H2i5
Genetic
Background		 NOD.Cg-H2i5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2i5 mutation (3 available); any H2 mutation (304 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:14178 )
• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

endocrine/exocrine glands
periinsulitis ( J:14178 )
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 5-7 months of age as do older mice (10-17 months of age); mice display perivascular and periductal infiltrates with or without cyclophosphamide treatment

immune system
periinsulitis ( J:14178 )
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 5-7 months of age as do older mice (10-17 months of age); mice display perivascular and periductal infiltrates with or without cyclophosphamide treatment
decreased susceptibility to autoimmune diabetes ( J:14178 )
• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation




Genotype
MGI:3628789
ht2
Allelic
Composition		 H2i5/H2g7
Genetic
Background		 NOD.Cg-H2i5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (304 available)
H2i5 mutation (3 available); any H2 mutation (304 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:14178 )
• no females develop diabetes spontaneously over 5-7 months




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory