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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nptxrtm1Mspn
targeted mutation 1, Mark S Perin
MGI:3628751
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nptxrtm1Mspn/Nptxrtm1Mspn involves: 129 * C57BL/6 MGI:3629081
cx2
 		Nptx1tm1Mspn/Nptx1tm1Mspn
Nptx2tm1Mspn/Nptx2tm1Mspn
Nptxrtm1Mspn/Nptxrtm1Mspn 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3629080


Genotype
MGI:3629081
hm1
Allelic
Composition		 Nptxrtm1Mspn/Nptxrtm1Mspn
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nptxrtm1Mspn mutation (0 available); any Nptxr mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal innervation ( J:109215 )
• at P10, mild expansion of the ipsalateral eye input into the dorsal lateral geniculate nucleus




Genotype
MGI:3629080
cx2
Allelic
Composition		 Nptx1tm1Mspn/Nptx1tm1Mspn
Nptx2tm1Mspn/Nptx2tm1Mspn
Nptxrtm1Mspn/Nptxrtm1Mspn
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nptx1tm1Mspn mutation (0 available); any Nptx1 mutation (26 available)
Nptx2tm1Mspn mutation (0 available); any Nptx2 mutation (23 available)
Nptxrtm1Mspn mutation (0 available); any Nptxr mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal innervation ( J:109215 )
• defects in segregation of retinal ganglion cell projections in the dorsal lateral geniculate nucleus are similar to those in mice double homozygous for the Nptx1 and Nptx2 alleles




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory