Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nptx1tm1Mspn mutation
(0 available);
any
Nptx1 mutation
(24 available)
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nervous system
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N |
• no obvious cerebral, cerebellar, or hippocampal ultrastructural abnormalities
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behavior/neurological
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N |
• no obvious changes of gait or behavior
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nptx1tm1Mspn mutation
(0 available);
any
Nptx1 mutation
(24 available)
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nervous system
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• at P10, mild expansion of the ipsalateral eye input into the dorsal lateral geniculate nucleus
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nptx1tm1Mspn mutation
(0 available);
any
Nptx1 mutation
(24 available)
Nptx2tm1Mspn mutation
(0 available);
any
Nptx2 mutation
(24 available)
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nervous system
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• at P10 retinal ganglion cell projections into the dorsal lateral geniculate nucleus (dLGN) lack eye specific segregation with projections from the contralateral filling the entire dLGN overlapping with single or multiple ipsalateral eye projection zones
• at P30 retinal ganglion cell projections appear to be separated; however, axons from the ispalateral eye continue to cover a larger area of the dLGN and multiple ipsalateral termination zones are seen rather than a single zone as in wild-type
• however, targeting of retinal ganglion cell axons through the optic chiasm is similar to wild-type
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vision/eye
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• retinal ganglion cells display increased average action potential burst duration mostly due to the absence of burst shorter than 1.5 sec in duration
• retinal ganglion cells have a significantly higher overall spike rate and a slightly higher instantaneous firing frequency; however the correlation between near and distant spikes is maintained
• retinal ganglion cells cultured for 2 weeks with wild-type glia show delayed development of glutamatergic synaptic function
• however, visual transmission and visually mediated behavior in adult mice is similar to wild-type and no defects in hippocampal function are detected at P20 - P40
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behavior/neurological
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N |
• visually mediated behavior in adult mice is similar to wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nptx1tm1Mspn mutation
(0 available);
any
Nptx1 mutation
(24 available)
Nptx2tm1Mspn mutation
(0 available);
any
Nptx2 mutation
(24 available)
Nptxrtm1Mspn mutation
(0 available);
any
Nptxr mutation
(9 available)
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nervous system
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• defects in segregation of retinal ganglion cell projections in the dorsal lateral geniculate nucleus are similar to those in mice double homozygous for the Nptx1 and Nptx2 alleles
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Analysis Tools