Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nptx1tm1Mspn targeted mutation 1, Mark S Perin MGI:3628746 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no obvious cerebral, cerebellar, or hippocampal ultrastructural abnormalities
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| N |
• no obvious changes of gait or behavior
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P10, mild expansion of the ipsalateral eye input into the dorsal lateral geniculate nucleus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P10 retinal ganglion cell projections into the dorsal lateral geniculate nucleus (dLGN) lack eye specific segregation with projections from the contralateral filling the entire dLGN overlapping with single or multiple ipsalateral eye projection zones
• at P30 retinal ganglion cell projections appear to be separated; however, axons from the ispalateral eye continue to cover a larger area of the dLGN and multiple ipsalateral termination zones are seen rather than a single zone as in wild-type
• however, targeting of retinal ganglion cell axons through the optic chiasm is similar to wild-type
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• retinal ganglion cells display increased average action potential burst duration mostly due to the absence of burst shorter than 1.5 sec in duration
• retinal ganglion cells have a significantly higher overall spike rate and a slightly higher instantaneous firing frequency; however the correlation between near and distant spikes is maintained
• retinal ganglion cells cultured for 2 weeks with wild-type glia show delayed development of glutamatergic synaptic function
• however, visual transmission and visually mediated behavior in adult mice is similar to wild-type and no defects in hippocampal function are detected at P20 - P40
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| N |
• visually mediated behavior in adult mice is similar to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• defects in segregation of retinal ganglion cell projections in the dorsal lateral geniculate nucleus are similar to those in mice double homozygous for the Nptx1 and Nptx2 alleles
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/07/2025 MGI 6.24 |
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