Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2tm1Pag mutation
(0 available);
any
Capn2 mutation
(34 available)
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mortality/aging
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• no homozygous embryos are found between E10.5 and E18.5; only 2/90 embryos isolated at E2.5 to 3.5 were homozygous
• no embryos examined at the 8-cell (blastocyst) stage are homozygous
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embryo
Allelic Composition |
Capn2tm1Pag/Capn2+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * CD-1 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2tm1Pag mutation
(0 available);
any
Capn2 mutation
(34 available)
|
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reproductive system
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• ratio of heterozygotes to wild-type offspring heavily favors heterozygotes; instead of 1:2 expected hets to wild-type, 23 wild-type to 176 heterosygotes is observed
• when mutant allele is maternally-derived, overrepresentation of heterozygotes is more pronounced than when mutant allele is transmitted by the male
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