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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt3btm6Enl
targeted mutation 6, En Li
MGI:3628446
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt3btm6Enl/Dnmt3btm6Enl involves: 129S4/SvJae * C57BL/6 MGI:3628830
ht2
 		Dnmt3btm6Enl/Dnmt3btm7Enl involves: 129S4/SvJae * C57BL/6 MGI:3628828
ht3
 		Dnmt3btm1Enl/Dnmt3btm6Enl involves: 129S4/SvJae * C57BL/6 MGI:3628914


Genotype
MGI:3628830
hm1
Allelic
Composition		 Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm6Enl mutation (0 available); any Dnmt3b mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:106540 )
• normal numbers of pups are born but most die within 24 hours

craniofacial
large anterior fontanelle ( J:106540 )
• enlarged front fontanelle is present in mutants
wide frontal bone ( J:106540 )
• calvarium of adult homozygotes has wider frontal bones than wild-type littermates resulting in a wider distance between the eyes
short nasal bone ( J:106540 )
• nasal bone of adults is shorter than in wild-type

growth/size/body
short nasal bone ( J:106540 )
• nasal bone of adults is shorter than in wild-type
decreased birth weight ( J:106540 )
• at birth, mutants are less than 2/3 the weight of normal littermates

hematopoietic system
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying
small thymus ( J:106540 )
• thymuses of P1 mutants are much smaller than those of controls

immune system
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying
small thymus ( J:106540 )
• thymuses of P1 mutants are much smaller than those of controls

skeleton
large anterior fontanelle ( J:106540 )
• enlarged front fontanelle is present in mutants
wide frontal bone ( J:106540 )
• calvarium of adult homozygotes has wider frontal bones than wild-type littermates resulting in a wider distance between the eyes
short nasal bone ( J:106540 )
• nasal bone of adults is shorter than in wild-type

vision/eye
ocular hypertelorism ( J:106540 )
• mutants display a wider distance between the eyes

cellular
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying

endocrine/exocrine glands
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying
small thymus ( J:106540 )
• thymuses of P1 mutants are much smaller than those of controls

respiratory system
short nasal bone ( J:106540 )
• nasal bone of adults is shorter than in wild-type




Genotype
MGI:3628828
ht2
Allelic
Composition		 Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm6Enl mutation (0 available); any Dnmt3b mutation (50 available)
Dnmt3btm7Enl mutation (0 available); any Dnmt3b mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:106540 )
• normal numbers of pups are born but most die within 24 hours
postnatal lethality, complete penetrance ( J:106540 )
• almost no (only 1) homozygous mice survive to weaning

growth/size/body
abnormal nasal bone morphology ( J:106540 )
• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3btm7Enl mutants
decreased birth weight ( J:106540 )
• at birth, mutants are less than 2/3 the weight of normal littermates

craniofacial
abnormal nasal bone morphology ( J:106540 )
• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3btm7Enl mutants

skeleton
abnormal nasal bone morphology ( J:106540 )
• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3btm7Enl mutants

immune system
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying

hematopoietic system
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying

cellular
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying

endocrine/exocrine glands
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying

respiratory system
abnormal nasal bone morphology ( J:106540 )
• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3btm7Enl mutants




Genotype
MGI:3628914
ht3
Allelic
Composition		 Dnmt3btm1Enl/Dnmt3btm6Enl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm1Enl mutation (1 available); any Dnmt3b mutation (50 available)
Dnmt3btm6Enl mutation (0 available); any Dnmt3b mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:106540 )
• normal numbers of pups are born but most die within 24 hours

immune system
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying

growth/size/body
decreased birth weight ( J:106540 )
• at birth, mutants are less than 2/3 the weight of normal littermates

hematopoietic system
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying

cellular
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying

endocrine/exocrine glands
increased thymocyte apoptosis ( J:106540 )
• at P1, many thymocytes are dead or dying




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory